孤独症谱系障碍儿童胃肠问题检出情况初探

发布时间：2018-04-24 07:08

本文选题：孤独症谱系障碍 + 胃肠问题　；参考：《上海交通大学学报(医学版)》2017年11期

【摘要】：目的·探索孤独症谱系障碍(ASD)儿童胃肠问题检出率及分布情况。方法·纳入在上海交通大学医学院附属上海儿童医学中心及附属新华医院发育行为儿科就诊的3~8岁ASD患儿336名。所有患儿均符合《精神疾病诊断与统计手册》第5版诊断标准。由父母或照养人填写患儿一般资料,包括出生年月、性别及近3个月胃肠问题现况等。探索胃肠问题在此人群中的检出率及分布情况。结果·336例ASD患儿中,胃肠问题阳性85例,总体检出率25.3%。其中便秘59例(17.6%),呕吐12例(3.6%),腹泻11例(3.3%),腹痛7例(2.1%),腹胀6例(1.8%)。在3~8岁合并胃肠问题的ASD儿童中,不同年龄组之间胃肠问题检出率的差异无统计学意义(χ~2=1.511,P=0.680),胃肠问题严重度的差异也无统计学意义(F=0.773,P=0.513)。结论·胃肠问题在ASD儿童中较常见,且在3~8岁年龄段持续存在,其严重度不随年龄增长而降低。提示ASD儿童胃肠问题,尤其是便秘,需作为慢病管理的一部分,其评估和治疗值得临床关注。
[Abstract]:Objective to investigate the prevalence and distribution of gastrointestinal problems in children with autism spectrum disorder (ASD). Methods A total of 336 children with ASD aged 3 years old from Shanghai Children's Medical Center and affiliated Xinhua Hospital of Shanghai Jiaotong University were enrolled in this study. All the children were in accordance with the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders. General information of the child, including year of birth, sex and status of gastrointestinal problems in the last 3 months, were filled in by parents or foster persons. To explore the detection rate and distribution of gastrointestinal problems in this population. Results of 336 cases of ASD, 85 cases were positive for gastrointestinal problems, the total detection rate was 25.3%. Among them, 59 cases had constipation, 12 cases had vomiting, 11 cases had diarrhea, 7 cases had abdominal pain, 7 cases had abdominal pain, and 6 cases had abdominal distention. There was no significant difference in the detection rate of gastrointestinal problems among different age groups in ASD children aged 3 to 8 years (蠂 ~ (2) 2 ~ (1.511) P ~ (0.680)), and there was no significant difference in the severity of gastrointestinal problems (P < 0.05 ~ (13)). Conclusion Gastrointestinal problems are more common in children with ASD and persist in the age group of 3 to 8 years. The severity of gastrointestinal problems does not decrease with the increase of age. It is suggested that gastrointestinal problems, especially constipation, in children with ASD should be considered as part of management of chronic diseases, and its evaluation and treatment are worthy of clinical attention.
【作者单位】：上海交通大学医学院附属上海儿童医学中心发育行为儿科;上海交通大学医学院附属新华医院环境与儿童健康教育部和上海市重点实验室;重庆医科大学附属儿童医院儿童保健科;上海交通大学医学院附属新华医院发育行为儿童保健科;
【基金】：国家自然科学基金(81270397) 上海市教育委员会高峰高原学科建设计划(20152234)~~
【分类号】：R725.7;R749.94

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