TAAR6基因多态性与精神分裂症关联性的Meta分析

发布时间：2018-04-24 12:02

  本文选题：TAAR基因 + 基因多态性　； 参考：《吉林大学学报(医学版)》2014年03期

【摘要】：目的:探讨人群中TAAR6基因多态性与精神分裂症的关联,阐明TAAR6基因与精神分裂症的关系。方法:通过计算机检索PubMed、Cochrance、中国知网(CNKI)和万方数据库,检索TAAR6基因多态性与精神分裂症关联的相关文献。检索时间为1994年1月—2013年5月公开发表的文献。根据纳入标准对相关文献进行筛查,选出合适的文献,提取文献中的数据。以比值比(OR)和95%可信区间(95%CI)为效应指标。采用RevMan 5.1软件对各项研究原始数据进行统计学分析,包括异质性检验、合并效应量以及评估发表偏倚。结果:按照纳入标准共有5篇文献符合条件,共选取了5个位点进行Meta分析,rs8192625位点的等位基因合并OR=0.93,95%CI=0.81~1.07,P=0.32;基因型合并OR=0.88,95%CI=0.76~1.02,P=0.08。rs4305745等位基因合并OR=0.96,95%CI=0.90~1.03,P=0.29;基因型合并OR=1.03,95%CI=0.92~1.14,P=0.62。rs6903874位点的等位基因合并OR=0.95,95%CI=0.86~1.04,P=0.27;基因型合并OR=0.93,95%CI=0.84~1.04,P=0.20。rs6937506位点的等位基因合并OR=0.95,95%CI=0.86~1.04,P=0.27;基因型合并OR=0.93,95%CI=0.83~1.03,P=0.17。rs7772821位点的等位基因合并OR=0.96,95%CI=0.87~1.05,P=0.35;基因型合并OR=0.96,95%CI=0.86~1.07,P=0.47。结论:人群中TAAR6基因5个位点的等位基因和基因型多态性与精神分裂症无关联,提示TAAR6基因多态性可能与精神分裂症无关联。
[Abstract]:Objective: to investigate the association between TAAR6 gene polymorphism and schizophrenia and to elucidate the relationship between TAAR6 gene and schizophrenia. Methods: a computer-based search of PubMedus Cochrance (CNKI) and Wanfang database was carried out to search the literature related to the association of TAAR6 gene polymorphism with schizophrenia. The search time is from January 1994 to May 2013. According to the inclusion criteria, the relevant documents are screened, the appropriate documents are selected, and the data from the literature are extracted. The ratio ratio (OR) and 95% CI (95% CI) were used as the effective indexes. The original data of each study were analyzed by RevMan 5.1 software, including heterogeneity test, combined effect quantity and evaluation bias. Results: according to the inclusion criteria, a total of 5 articles were eligible, 鍏遍，

本文编号：1796542