身体活动对改善药物成瘾戒断者脑功能损伤的研究——来自抑制加工及脑功能静息态的证据

发布时间：2018-04-24 17:54

本文选题：药物成瘾 + 身体活动　；参考：《武汉体育学院学报》2017年05期

【摘要】：目的:探讨身体活动对药物成瘾戒断者抑制能力及静息态脑功能的改善,拟为药物成瘾提供有效的辅助治疗手段。方法:将药物成瘾戒断者按身体活动量分为活动组和久坐组,首先进行Go/NoGo抑制能力测试,然后采集他们的静息态功能磁共振数据。选取静息态的两项重要分析方法——低频振幅(amplitude of low frequency fluctuations,ALFF)和局部一致性(regional homogeneity,ReHo)来探讨身体活动对药物成瘾戒断者脑功能损伤的改善。结果:(1)Go/NoGo测试:活动组NoGo正确率显著高于久坐组。(2)ALFF分析:活动组在双侧脑岛、左侧额下回眶部、双侧额内侧回、左侧前扣带回、右侧背外侧前额叶、左侧枕上回、左侧辅助运动区、双侧内侧扣带回ALFF显著高于久坐组。(3)ReHo分析:活动组在左侧枕中回、双侧背外侧前额叶、左侧辅助运动区ReHo显著高于久坐组。这些显著差异脑区主要与成瘾的抑制能力有关。结论:(1)身体活动能有效地提高药物成瘾戒断者的抑制能力。(2)身体活动是修复药物成瘾戒断者大脑功能损伤的关键因素之一。身体活动可通过增加药物成瘾戒断者静息状态下脑功能的低频振幅和局部一致性,改善药物成瘾戒断者大脑功能损伤。
[Abstract]:Objective: to explore the improvement of inhibition ability and resting brain function of drug addicts by physical activity in order to provide effective adjuvant therapy for drug addiction. Methods: drug addicts were divided into active group and sedentary group according to their physical activity. The inhibition ability of Go/NoGo was tested firstly, and then their resting functional magnetic resonance (fMRI) data were collected. Two important analytical methods of resting state, low frequency amplitude of low frequency structures (ALFFF) and regional homogenicity (ReHoA), were selected to study the improvement of brain function damage in drug addiction abstinent patients by physical activity. Results: the accuracy of NoGo in the activity group was significantly higher than that in the sedentary group. Results: the correct rate of NoGo in the active group was significantly higher than that in the sedentary group: bilateral cerebral islands, orbital part of left inferior frontal gyrus, bilateral medial frontal gyrus, left anterior cingulate gyrus, right dorsolateral prefrontal lobe, left superior occipital gyrus. The ALFF of bilateral medial cingulate gyrus in left auxiliary motor area was significantly higher than that in sedentary group. The ReHo of active group was significantly higher than that of sedentary group in left middle occipital gyrus, bilateral dorsolateral prefrontal lobe and left auxiliary motor area. These significant differences in brain regions are mainly related to the inhibition of addiction. Conclusion 1) physical activity can effectively improve the inhibition ability of drug addicts. 2) physical activity is one of the key factors in repairing brain function damage in drug addicts. Physical activity can improve brain function injury of drug addicts by increasing low frequency amplitude and local consistency of brain function in resting state of drug addicts.
【作者单位】：上海体育学院运动科学学院;
【基金】：国家自然科学基金项目(31571151) 上海体育学院研究生教育创新基金项目(yjscx2016015) 上海市科委研究项目(13490503600)
【分类号】：R749.6

【相似文献】