温胆汤联合抗精神病药物治疗精神分裂症疗效与安全性的Meta分析

发布时间：2018-04-24 20:06

本文选题：温胆汤 + 精神分裂症　；参考：《中华中医药学刊》2017年10期

【摘要】：目的:系统评价温胆汤联合抗精神病药物治疗精神分裂症(Schizophrenia SZ)的临床疗效和安全性。方法:计算机检索相关期刊论文(CNKI)、万方数字化期刊全文数据库(Wanfang data)、维普中文科技期刊数据库(VIP)、Pubmed、Annual Reviews、Special Sci等数据库温胆汤联合抗精神病药物治疗SZ的临床随机对照试验,应用Jadad评分法和Cochrane手册5.1标准对纳入文献进行质量评价,采用review manager 5.2软件进行Meta分析。结果:纳入9项研究,共993例受试者,文献质量较低。Meta分析显示,试验组治疗SZ较对照组能提高有效率、痊愈率[OR=2.56,95%CI(1.72,3.82),P0.000 01]、[OR=1.89,95%CI(1.40,2.54),P0.000 01],降低阳性与阴性症状量表(PANSS)评分、锥体外系不良反应发生率[MD=-9.70,95%CI(-12.34,-7.03),P0.000 01]、[OR=0.29,95%CI(0.18,0.46),P0.000 01]。结论:温胆汤联合抗精神病药物治疗SZ较单纯抗精神病药物有更好的临床疗效和安全性,但仍需高质量的临床随机对照试验进一步证实。
[Abstract]:Objective: to evaluate the clinical efficacy and safety of Wendan decoction combined with antipsychotic drugs in the treatment of schizophrenia (Schizophrenia SZ). Methods: a randomized controlled clinical trial was conducted to search the Chinese periodical full-text database (CNKI), Wanfang Datahe (Wanfang), Weipu (Chinese Science and Technology Journals) database, such as Wendan decoction (Wentan decoction) combined with antipsychotic drugs (SZ). Jadad scoring method and Cochrane Manual 5.1 standard were used to evaluate the quality of the literature included, and review manager 5.2 software was used to carry out Meta analysis. Results: a total of 993 subjects were included in 9 studies. The literature quality was low. Meta-analysis showed that the effective rate of treatment SZ in the trial group was higher than that in the control group, and the cure rate was 1.723.82% (P 0.00001), [the CI1.802.54% P0.00001], and the PANSS score of the positive and negative symptoms scale was decreased. The incidence of adverse reactions in extrapyramidal system [MD-9.70 ~ 95CI-12.34 ~ 7.03 P0.00001], [OR-0.29 ~ 95CII 0.18 ~ 0.46 / P0.00001]. Conclusion: Wendan decoction combined with antipsychotics has better clinical efficacy and safety than simple antipsychotics, but it still needs to be confirmed by high quality randomized controlled trial.
【作者单位】：江西中医药大学;
【基金】：国家自然科学基金项目(81160423)
【分类号】：R749.3

【相似文献】