青少年首发未用药精神分裂症患者脑灰质改变

发布时间：2018-04-25 00:23

本文选题：精神分裂症 + 灰质　；参考：《中国神经精神疾病杂志》2014年06期

【摘要】：目的探讨青少年首发未用药精神分裂症患者的脑灰质结构损害特征及其与临床特征的相关性。方法应用GE 3.0T磁共振成像仪对26例青少年首发精神分裂症患者与26名青少年正常对照进行头颅结构磁共振扫描获得3D脑结构图像,采用基于变形场理论的最新形态学配准技术(diffeomorphic anatomi-cal registration using the exponentiated lie algebra,DARTEL)对脑灰质体积进行分析,并对患者异常的灰质体积与临床症状严重程度进行相关性分析。结果与对照组相比,患者组灰质体积下降区域为左侧顶叶中央后回、边缘叶海马旁回以及右侧小脑后叶蚓锥体,两组间差异均有统计学意义(P0.001,未校正)。偏相关分析显示,左侧海马旁回灰质体积与PANSS偏执分(r=-0.49,P=0.02)存在相关,余灰质损害脑区与临床特征均无统计学相关性(P0.05)。结论青少年首发精神分裂症患者脑结构损害模式为小脑—边缘叶(海马旁回)—顶叶的脑结构异常,患者的偏执症状与左侧海马旁回灰质损害有关。
[Abstract]:Objective to investigate the characteristics of gray matter structure damage and its correlation with clinical features in adolescents with first-episode schizophrenia. Methods using GE 3.0T magnetic resonance imaging instrument, 26 adolescents with first-episode schizophrenia and 26 normal controls were examined with brain structure MRI to obtain 3D brain structure images. The latest morphologic registration technique based on deformation field theory (anatomi-cal registration using the exponentiated lie algebra) was used to analyze the volume of gray matter, and the correlation between the abnormal volume of gray matter and the severity of clinical symptoms was analyzed. Results compared with the control group, the decreased gray matter volume in the patients group was located in the left posterior parietal gyrus, the paracarpal gyrus of the marginal lobe and the right trabecula of the posterior cerebellum. The difference between the two groups was statistically significant (P 0.001). Paranoid correlation analysis showed that there was a correlation between the volume of gray matter in the left para-hippocampal gyrus and the PANSS paranoid score r-0.49 (P0.02). There was no significant correlation between the residual gray matter damage and the clinical features (P 0.05). Conclusion the pattern of brain structure damage in adolescents with first-episode schizophrenia is the abnormal structure of cerebellar and marginal lobe (para-hippocampal gyrus and parietal lobe). The paranoid symptoms of the patients are related to the damage of gray matter in the left parahippocampal gyrus.
【作者单位】：四川大学华西心理卫生中心;
【基金】：国家自然科学基金(编号:81130024);国家自然科学基金(编号:30530300);国家自然科学基金(编号:91332205) 科技部十二五支撑计划(编号:2012BAI01B06) 教育部博士点新教师基金(编号:20110181120033)
【分类号】：R749.3

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