色氨酸羟化酶2基因多态性与抑郁症及自杀企图的关系

发布时间：2018-04-25 04:18

本文选题：抑郁症 + 自杀企图　；参考：《广东医学》2014年24期

【摘要】：目的探讨色氨酸羟化酶2(TPH2)基因启动子区的-8396G/C(rs4131347)、第7外显子区的rs7305115 A/G单核苷酸多态性与抑郁症及自杀企图的关系。方法提取105例有自杀企图的抑郁症患者、102例无自杀企图的抑郁症患者和100例健康对照者的基因组DNA,应用聚合酶链式反应-限制性片段长度多态性技术检测THP2基因多态性。结果抑郁症患者和健康对照者TPH2 rs4131347、rs7305115基因型和等位基因频率差异无统计学意义(P0.05)。有自杀企图的抑郁症患者与无自杀企图的抑郁症患者TPH2 rs4131347基因型和等位基因频率差异无统计学意义(P0.05)。rs7305115位点基因型及等位基因分布频率在抑郁症有、无自杀企图患者之间的差异有统计学意义(P0.05);抑郁症有自杀企图患者内的个体携带TPH2 rs7305115基因型AA的频率及等位基因A的频率均较低,差异有统计学意义(P0.01)。结论 TPH2基因rs4131347、rs7305115单核苷酸多态性与抑郁症无明显关联。TPH2基因rs7305115位点AA基因型和A等位基因可能与抑郁症的自杀企图有关联,其可能是抑郁症的自杀企图的保护因素。
[Abstract]:Objective to investigate the relationship between the rs7305115 A / G single nucleotide polymorphisms in the promoter region of tryptophan hydroxylase 2 (TPH2) gene (-8396G / Cnrs4131347) and exon 7 (exon 7) with depression and suicide attempts. Methods the genomic DNAs were extracted from 105 depression patients with suicide attempt and 100 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (RFLP) was used to detect the polymorphism of THP2 gene. Results there was no significant difference in genotype and allele frequency of TPH2 rs41347-rs7305115 between patients with depression and healthy controls (P 0.05). There was no significant difference in the frequency of TPH2 rs4131347 genotype and allele between the depression patients with suicide attempt and the depression patients without suicide attempt. The frequency of TPH2 rs7305115 genotype AA and allele A in patients with depression with suicide attempt was lower than that in patients without suicide attempt (P 0.05), and the difference was statistically significant (P 0.01). Conclusion the single nucleotide polymorphisms of TPH2 gene rs41347rs7305115 have no significant association with depression. The AA genotype and A allele of rs7305115 locus of TPH2 gene may be associated with suicide attempt of depression, which may be the protective factor of suicide attempt in depression.
【作者单位】：广东省广州市精神病医院情感障碍科;广东省广州市精神病医院成人精神科;广东省广州市精神病医院心理科;
【基金】：广东省医学科研基金立项课题(编号:A2010485)
【分类号】：R749.4

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