睾酮与青少年分裂型人格障碍的相关研究

发布时间：2018-04-30 13:12

本文选题：分裂型人格障碍 + 睾酮　；参考：《大连医科大学》2012年硕士论文

【摘要】：目的：探讨男性青少年分裂型人格障碍人群与正常人群之间的睾酮水平差异。重点探讨青春期睾酮水平在分裂型人格障碍形成中的作用,以及睾酮水平对分裂型人格障碍各临床症状维度的影响。方法：应用MMPI-566（明尼苏达多项人格测试）对某大学2011年3500名入学男性新生进行普查，，符合MMPI的4,6,8编码者，SC尺度分值大于70分，且F值在65~79分值范围内者被作为分裂型人格特征阳性者，再经2名精神科主治医师使用DSM-IV分裂型人格障碍结构性访谈问卷筛选出50名分裂型人格特征阳性者作为实验组。随机选取MMPI各个临床尺度在正常范围内的学生50名为健康对照组。采用一般问卷、分裂型人格问卷(Schizotypal personality questionnaire, SPQ)对两组人群进行调查；为了观测胎儿期间暴露于睾酮水平,2D:4D比值被测量；为了进一步的观察是否母孕季节是女性高睾酮分泌期,所有被试的母亲怀孕季节被调查；采用电化学发光法测定分析血清游离睾酮水平。结果：①分裂型人格障碍组（n=50）与正常对照组（n=50）的睾酮水平在两组间差异显著（t=2.319,p=0.023）；②母亲怀孕季节分布在分裂型人格障碍组与正常对照组之间差异不显著（2=1.250,p=0.741）；③分裂型人格障碍组左手2D:4D比值与正常对照组之间差异不显著（t=0.259, p=0.796）；④分裂型人格障碍组中睾酮水平与SPQ怪异信念呈显著正相关（r=0.382,p=0.011）；⑤分裂型人格障碍组内高低睾酮组间SPQ因子分比较，怪异信念得分高睾酮水平组显著高于低睾酮水平组（t=2.509,p=0.020）；⑥回归分析结果发现，睾酮水平是分裂型人格障碍怪异信念及精神分裂质的危险因素。结论：①首次明确分裂症易感人格群体的分裂型人格障碍组睾酮水平显著高于正常对照组；②母亲怀孕季节分布在分裂型人格障碍组与正常对照组之间差别不显著；2D:4D比值也未提示分裂型人格障碍组较正常对照组在胎儿时期过多暴露于睾酮。所以我们认为青春期睾酮水平急剧增加对分裂型人格障碍的形成才是至关重要的。③睾酮是影响怪异信念的首要因素，并且怪异信念可能是精神分裂症或分裂型人格障碍的早期行为特征。青春期睾酮水平偏高很可能作为分裂症早期症状的生物学标志。
[Abstract]:Objective: to explore the difference of testosterone levels between male adolescents with split personality disorder and normal subjects. To explore the role of adolescent testosterone level in the formation of split personality disorder and the effect of testosterone level on the clinical symptom dimensions of split personality disorder. Methods: a total of 3500 male freshmen enrolled in a university in 2011 were surveyed by MMPI-566 (Minnesota Personality Test). The SC-scale scores of the 4MMPI-566 encoders in accordance with MMPI were greater than 70. The F value in the range of 650.79 was regarded as positive for split personality, and 50 split personality traits were selected as experimental group by two psychiatrists using DSM-IV split personality disorder structured interview questionnaire. 50 students with normal clinical scale of MMPI were randomly selected as healthy control group. A general questionnaire and a split personality questionnaire (Schizotypal personality questionnaire, SPQ) were used to investigate the two groups; to measure the ratio of 2D: 4D to testosterone level during fetal exposure; and to further investigate whether the maternal pregnancy season was a period of high testosterone secretion in women. All mothers were investigated during pregnancy and serum free testosterone levels were determined by electroluminescence assay. Results there was significant difference between the two groups in the testosterone level between the two groups. There was no significant difference between the two groups in the pregnant season between the two groups. There was no significant difference between the split personality disorder group and the normal control group. There was no significant difference between the two groups in the level of testosterone in the two groups, and the difference was not significant in the split personality disorder group and the normal control group. There was no significant difference in the level of testosterone between the two groups. There was no significant difference between the left hand 2D:4D ratio of the personality disorder group and the normal control group. There was no significant difference between the left hand 2D:4D ratio and the normal control group. There was a significant positive correlation between testosterone level and SPQ weird belief in the split personality disorder group. There was a significant positive correlation between the high and low testosterone factor scores in the split personality disorder group and the SPQ factor score in the high and low testosterone group. The results of regression analysis showed that the level of testosterone was a risk factor of schizophrenia personality disorder. Conclusion the testosterone level in the split personality disorder group was significantly higher than that in the normal control group. 2There was no significant difference of 2D: 4D ratio between the split personality disorder group and the normal control group during pregnancy season, nor did it indicate that the split personality disorder group was more exposed to testosterone in the fetal period than the normal control group. So we think that a sharp rise in adolescent testosterone is the most important factor in the formation of split personality disorders, and that testosterone is the primary factor that affects weird beliefs. And weird beliefs may be an early behavioral feature of schizophrenia or schizophrenic personality disorder. The high level of testosterone in adolescence may be used as a biological marker of early symptoms of schizophrenia.
【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.94

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