氧化低密度脂蛋白和血脂水平与血管性痴呆的相关性研究

发布时间：2018-05-04 01:39

本文选题：氧化低密度脂蛋白 + 血脂水平　；参考：《哈尔滨医科大学学报》2014年04期

【摘要】：目的探讨氧化低密度脂蛋白(oxidized low density lipoprotein,Ox-LDL)和血脂水平与血管性痴呆(vascular dementia,VaD)的相关性。方法纳入均符合NINDS-AIREN(美国国立精神系统疾病与卒中研究所和瑞士神经科学研究国际协会,1993年)诊断标准的VaD患者,VaD组(n=25)及对照组(n=17)。以全自动生化分析仪检测两组患者的血脂水平,并采用酶联免疫吸附试验(enzyme-linked immunosorbnent assay,ELISA)检测两组患者的Ox-LDL水平。结果 VaD组Ox-LDL平均(3.17±2.02)mg/L,对照组(1.23±1.39)mg/L,且有统计学差异(P=0.001)。VaD组男性Ox-LDL(3.01±1.85)mg/L明显高于对照组男性(1.25±1.30)mg/L,且VaD组女性Ox-LDL(4.18±3.20)mg/L明显高于对照组女性(1.22±1.55)mg/L,有明显差异(P=0.027)。两组血脂成分无明显差异。两组血浆Ox-LDL含量与各血脂成分均未见明显相关(P0.05)。VaD组患者血浆Ox-LDL浓度与MoCa结果未见明显相关性(P0.05),与年龄未见明显相关(P0.5)。结论 VaD患者血浆Ox-LDL含量明显增高,血浆Ox-LDL的检测可能有助于临床上对VaD的诊断。
[Abstract]:Objective to investigate the relationship between oxidized low density lipoprotein (low density lipoprotein) Ox-LDL and serum lipids and vascular dementia (VD). Methods the patients with VaD who met the diagnostic criteria of NINDS-AIREN (National Institute of Psychiatric Diseases and Stroke and Swiss International Association for Neuroscientific Research, 1993) were included in the VaD group (n = 25) and the control group (n = 17). The serum lipids of the two groups were measured by automatic biochemical analyzer, and the Ox-LDL levels of the two groups were detected by enzyme linked immunosorbent assay (Elisa). Results the average Ox-LDL of VaD group was 3.17 卤2.02 mg / L, and that of control group was 1.23 卤1.39 mg / L, and the Ox-LDL(3.01 卤1.85)mg/L in male group was significantly higher than that in control group (1.25 卤1.30 mg / L), and the Ox-LDL(4.18 卤3.20)mg/L in VaD group was significantly higher than that in control group (1.22 卤1.55 mg / L, P 0.027). There was no significant difference in blood lipid composition between the two groups. There was no significant correlation between plasma Ox-LDL content and blood lipid components in both groups. There was no significant correlation between plasma Ox-LDL concentration and MoCa results in the two groups, and there was no significant correlation between plasma Ox-LDL concentration and age. Conclusion the level of plasma Ox-LDL in patients with VaD is significantly higher, and the detection of plasma Ox-LDL may be helpful in clinical diagnosis of VaD.
【作者单位】：哈尔滨医科大学附属第二医院神经内科;
【分类号】：R749.13

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