抑郁症患者静息态功能磁共振成像与抑郁严重程度相关性研究

发布时间：2018-05-04 13:26

本文选题：抑郁症 + 静息态功能磁共振成像　；参考：《中国全科医学》2014年07期

【摘要】：目的应用静息态功能磁共振成像(fMRI)局部一致性(ReHo)方法探讨抑郁症患者静息态脑活动特点;结合自评抑郁量表(SDS)探讨抑郁程度与静息自发脑活动相关性。方法 2012年6—12月于河北医科大学第二医院精神心理科对10例抑郁症患者(抑郁组)及10名与之相匹配的健康志愿者(对照组)进行静息态功能磁共振成像,采用ReHo方法分析数据,研究两组受试者静息态ReHo值差异,并对抑郁组SDS得分与差异脑区ReHo值行相关分析。结果抑郁组ReHo值减低脑区:右距状回,右枕中回,左楔叶,双侧额中回、眶回、前扣带回,右缘上回、中央后回;ReHo值增加脑区:左壳核、海马、海马旁回,右壳核、尾状核头、内囊前肢、海马,左顶下小叶,左额上回腹侧。SDS评分与ReHo值相关性:与左前扣带回、眶回(r=-0.87),右额中回(r=-0.82)ReHo值呈负相关,与左楔叶(r=0.82)ReHo值呈正相关。结论静息状态下抑郁症患者皮层同步一致性活动减弱,边缘系统、基底核活动增强;抑郁程度与左前扣带回、眶回、右额中回及左楔叶ReHo值相关。
[Abstract]:Objective to investigate the characteristics of resting brain activity in depression patients with resting functional magnetic resonance imaging (fMRI) and to explore the correlation between depression and resting spontaneous brain activity with self rating depression scale (SDS). Methods from June to December 2012, 10 patients with depression (depression group) and 10 matched healthy volunteers (control group) were studied by resting functional magnetic resonance imaging (fMRI) in Department of Psychiatology, second Hospital of Hebei Medical University. The ReHo method was used to analyze the difference of resting ReHo between the two groups, and the correlation analysis was made between the SDS score of depression group and the ReHo value of different brain area. Results in the depression group, the reduced ReHo values in the right talus gyrus, right middle occipital gyrus, left wedge lobe, bilateral middle frontal gyrus, orbital gyrus, anterior cingulate gyrus, right supramarginal gyrus, posterior central gyrus, right putamen nucleus, caudate nucleus were increased. The correlation between the anterior limb of the internal capsule, hippocampus, left inferior parietal lobule, left superior frontal gyrus ventral. SDS score and ReHo value: it was negatively correlated with the left anterior cingulate gyrus, orbital gyrus, and right middle frontal gyrus, and was positively correlated with the value of r 0.82 ReHo in the right middle frontal gyrus, and was negatively correlated with the left anterior cingulate gyrus, the orbital gyrus, and the right middle frontal gyrus. Conclusion in patients with depression at rest, the consistent activity of cortex is decreased, the activity of marginal system and basal nucleus is increased, and the degree of depression is related to the ReHo values of left anterior cingulate gyrus, orbital gyrus, right middle frontal gyrus and left cuneiform lobe.
【作者单位】：河北医科大学第二医院精神心理科;河北医科大学第二医院影像科;
【分类号】：R749.4

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