首发重度抑郁症患者不同亚类T淋巴细胞产生主要细胞因子水平的研究

发布时间：2018-05-05 07:58

本文选题：首发重度抑郁症 + 亚类T淋巴细胞　；参考：《中国现代医学杂志》2016年17期

【摘要】：目的观察首发重度抑郁症患者不同亚类T淋巴细胞产生主要细胞因子水平的变化。方法选取2014年3月-2014年11月该院首发重度抑郁症患者30例为研究对象,按治疗前和治疗后留取血清样本,酶联免疫吸附试验检测血清细胞因子水平,30例健康体检者为对照组;用汉密尔顿抑郁量表(HAMD)评价患者抑郁程度,抑郁组治疗前后血清细胞因子水平与HAMD各因子分进行Spearman相关性分析。结果抑郁组治疗前血清中干扰素-γ(IFN-γ)、白介素-9(IL-9)水平高于对照组(P0.05);抑郁组治疗前IFN-γ水平与胃肠道症状呈负相关,与疑病呈正相关(P0.05);IL-4水平与早醒呈负相关(P0.05);IL-9水平与睡眠不深、疑病呈正相关(P0.05),与自卑感呈负相关(P0.05);IL-17水平与胃肠道症状呈负相关(P0.05);抑郁组治疗后IFN-γ水平与忧郁情绪、性行为呈负相关(P0.05);IL-9水平与工作和兴趣呈正相关(P0.05),与全身症状、绝望感呈负相关(P0.05);IL-17水平与疑病呈正相关(P0.05)。结论首发重度抑郁症患者存在免疫失衡,细胞因子可能参与重度抑郁症的发生、发展。
[Abstract]:Objective to observe the changes of cytokines produced by different subtypes of T lymphocytes in patients with first-episode severe depression. Methods from March 2014 to November 2014, 30 patients with first episode severe depression in our hospital were selected as study subjects. Serum samples were collected before and after treatment, and serum cytokines levels were detected by Elisa in 30 healthy persons as control group. The degree of depression was evaluated by Hamilton Depression scale (Hamd). The Spearman correlation between serum cytokines and HAMD scores was analyzed before and after treatment in depression group. Results before treatment, the levels of IFN- 纬 -IFN- 纬 and IL-9 in serum of depression group were higher than those of control group (P 0.05), the level of IFN- 纬 was negatively correlated with gastrointestinal symptoms before treatment in depression group, and the level of IL-4 was positively correlated with suspected disease. The level of IL-17 was negatively correlated with gastrointestinal symptoms in depression group and depression group, and the level of IL-9 in sexual behavior was positively correlated with work and interest in depression group, and was positively correlated with symptoms of the whole body, while the level of IL-17 was negatively correlated with symptoms of gastrointestinal tract after treatment in depression group, and the level of IL-9 in sexual behavior was positively correlated with work and interest, while the level of IL-17 was negatively correlated with symptoms of gastrointestinal tract in depression group. A negative correlation was found between the level of IL-17 and the level of IL-17 in patients with hypochondriasis. Conclusion there is immune imbalance in first-episode patients with severe depression, and cytokines may be involved in the occurrence and development of severe depression.
【作者单位】：贵州省第二人民医院检验科;贵州省第二人民医院心身科;
【基金】：基金项目:贵州省科教青年英才培养工程[No:黔省专合字(2012)194号]
【分类号】：R749.4

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