血液中Aβ1-42和P-tau-181对阿尔茨海默病临床诊断的应用价值

发布时间：2018-05-05 13:19

本文选题：阿尔茨海默病 + β淀粉样蛋白-　；参考：《医学与哲学(B)》2017年11期

【摘要】：探讨血液中β淀粉样蛋白1-42(Aβ1-42)、磷酸化tau-181(P-tau-181)对阿尔茨海默病的诊断价值。采用ELISA方法检测阿尔茨海默病患者、非阿尔茨海默病痴呆患者、健康中老年人血液中Aβ1-42和P-tau-181的浓度。阿尔茨海默病组Aβ1-42浓度低于非阿尔茨海默病痴呆组(P=0.005)和健康对照组(P=0.000),P-tau-181的浓度高于非阿尔茨海默病痴呆组(P=0.000)和健康对照组(P=0.000)。利用ROC曲线发现,Aβ1-42和P-tau-181对于诊断阿尔茨海默病的灵敏度分别为65.3%、63.6%,特异性分别为76.4%、73.1%;而应用Aβ1-42/P-tau-181的比值诊断阿尔茨海默病的灵敏度为80.0%,特异性为85.1%。Aβ1-42/P-tau-181的比值作为诊断指标其灵敏度和特异性较高,对阿尔茨海默病的诊断有较大的应用价值。
[Abstract]:To investigate the diagnostic value of 尾 -amyloid protein 1-42A 尾 1-42, phosphorylated tau-181 (P-tau-181) in the diagnosis of Alzheimer's disease. The levels of A 尾 1-42 and P-tau-181 in the blood of Alzheimer's disease patients, non-Alzheimer 's disease dementia patients and healthy elderly people were detected by ELISA method. The concentration of A 尾 1-42 in Alzheimer disease group was lower than that in non-Alzheimer disease dementia group (P0. 005) and in healthy control group (P 0. 000 P tau-181) higher than that in non Alzheimer disease dementia group (P 0. 000) and healthy control group (P 0. 000). The sensitivity of A 尾 1-42 and P-tau-181 in the diagnosis of Alzheimer's disease was 65.3 and the specificity was 76.44.43 and 73.1, respectively, while the sensitivity of A 尾 1-42/P-tau-181 and the ratio of A 尾 1-42/P-tau-181 to diagnosis of Alzheimer's disease were 80.0 and 85.1, respectively, and the specificity of A 尾 1-42/P-tau-181 was 85.1. A 尾 1-42/P-tau-181 as diagnostic index. Its sensitivity and specificity are high, It is of great value in the diagnosis of Alzheimer's disease.
【作者单位】：大连市第三人民医院检验科;大连医科大学检验医学院;大连医科大学附属第一医院检验科;
【基金】：2017年辽宁省教育科学“十三五”规划课题(JG17DB125)
【分类号】：R749.16

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