河北省精神卫生机构老年抑郁症患者药物使用的调查分析

发布时间：2018-05-06 04:22

本文选题：河北省 + 精神卫生机构　；参考：《中国药房》2017年21期

【摘要】：目的:为老年抑郁症患者合理用药提供参考。方法:选取2012年7月2-9日河北省11市39家精神卫生机构的门诊及住院老年抑郁症患者96例,采用自制调查问卷并结合处方/医嘱查阅对其药物使用情况进行调查,并就调查数据进行统计和分析。结果:本研究共发放问卷96份,回收有效问卷96份,有效回收率为100%。96例受访患者中,95例使用新型抗抑郁药,以选择性5-羟色胺再摄取抑制剂(SSRIs)为主(占75.0%);使用例数排前5位的分别是舍曲林(23例,占24.0%,日剂量:25~200 mg)、帕罗西汀(22例,占22.9%,日剂量:20~60 mg)、艾司西酞普兰(20例,占20.8%,日剂量:5~40 mg)、文拉法辛(13例,占13.5%,日剂量:75~300 mg)、米氮平(12例,占12.5%,日剂量:8~30 mg)。96例受访患者中,22例(占22.9%)单独使用1种抗抑郁药,其余74例(占77.1%)为联合用药,其中47例为2种药联用,22例为3种药联用,4例为4种药联用,1例为5种药联用;联用心境稳定剂的有6例,联用抗精神病药的有21例,联用苯二氮卓类药物的有50例(其中6例联用2种苯二氮卓类药物),联用其他类型安眠药的有2例,联用抗焦虑药的有14例,联用抗胆碱药的有2例。结论:河北省精神卫生机构老年抑郁症患者用药基本符合当前趋势,但仍存在用药剂量达到或超过规定的最高剂量、联合用药品种偏多或方式不当等不合理用药现象。
[Abstract]:Objective: to provide reference for the rational use of drugs in elderly patients with depression. Methods: 96 outpatients and inpatients with senile depression were selected from 39 mental health institutions in 11 cities of Hebei Province from July 2 to 9, 2012. The drug use was investigated by self-made questionnaire and prescription / doctor's advice. And carries on the statistics and the analysis to the survey data. Results: a total of 96 questionnaires were sent out and 96 valid questionnaires were collected. The effective recovery rate was 100. 96 cases. 95 cases used new antidepressants. SSRIsa, a selective serotonin reuptake inhibitor (75.0%), was used in 23 cases (24.0%) of sertraline, 22 cases (22.9mg / d) of paroxetine, 20 cases (20 / d) of estradiolam. The daily dose was 20. 8. The daily dose was 5: 540 mg / g, the daily dose of venlafaxine was 13. 5%. The daily dose was 1: 7575, 300 mg / g, 12 / d, accounting for 12. 5%. 22 cases (22. 9%) were treated with one antidepressant alone (22. 9%) and the other 74 cases (77. 1%) were treated with one antidepressant drug at the daily dose of 20. 8% (22. 9%), and the other 74 cases (77. 1%) were treated with 1 antidepressant alone. Among them, 47 cases were 2 drugs combined with 22 cases, 3 kinds of drugs combined with 4 cases, 4 cases of 4 kinds of drugs combined with 1 case, 1 case of 5 kinds of drugs, 6 cases of combined use of mood stabilizer, 21 cases of combination of antipsychotic drugs, 50 cases were treated with benzodiazepines (6 cases with 2 benzodiazepines, 2 cases with other types of hypnotics, 14 cases with anti-anxiety drugs and 2 cases with anticholine drugs). Conclusion: the medication of senile depression patients in mental health institutions in Hebei Province is basically in line with the current trend, but there are still unreasonable drug use phenomena, such as dosage reaching or exceeding the prescribed maximum dose, the variety of combined use is too many or the way is not proper, etc.
【作者单位】：河北省第六人民医院;河北省直属机关第一门诊部;
【基金】：河北省医学科学研究重点课题计划(No.20130387)
【分类号】：R749.4

【参考文献】