儿茶酚胺氧位甲基转移酶基因多态性与疼痛的相关性研究

发布时间：2018-05-12 07:15

本文选题：疼痛 + COMT基因　；参考：《中国疼痛医学杂志》2014年04期

【摘要】：疼痛感觉受环境和遗传因素影响,个体对疼痛的敏感性与遗传因素有关。已发现多种基因变异与疼痛相关。儿茶酚胺氧位甲基转移酶(catechol-O-methyltransferase,COMT)主要功能是代谢具有毒性或生物活性的儿茶酚胺类物质及降解外周系统的多巴胺。目前COMT基因有293个单核苷酸多态,研究最多最有意义的基因多态性是第4号外显子1947位(rs 4680)上G→A,密码子108/158位缬氨酸变为蛋氨酸。COMT有3个最常见的单倍体型:低疼痛敏感型单倍体型(LPS)、中疼痛敏感型单倍体型(APS)、高疼痛敏感型单倍体型(HPS)[1]。APS/HPS二倍体型杂合子的疼痛阈值和耐受力最高,APS/APS二倍体型纯合子中等,LPS/LPS二倍体型纯合子最低。COMT多态性与多种疼痛相关,如骨骼肌疼痛、纤维肌痛症、术后痛、头痛及神经性疼痛,但结果常存在差异,需深入研究。
[Abstract]:Pain sensation is affected by environmental and genetic factors, and individual sensitivity to pain is related to genetic factors. Multiple genetic variants have been found to be associated with pain. The main function of catechol-O-methyltransferase COMTs is to metabolize catechol-O-methyltransferaseCOMTs with toxic or bioactive catecholamines and to degrade dopamine in peripheral systems. There are 293 single nucleotide polymorphisms in COMT gene. The most significant gene polymorphisms studied were G Aon on exon 4 at 1947 position rs4680, and codon 108 / 158 valine to methionine. COMT had three most common haploid types: low pain sensitive haploid, moderate pain sensitivity. The pain threshold and tolerance of APS / APS diploid heterozygotes were the highest. The lowest .COMT polymorphism of LPS / LPS diploid heterozygotes was associated with multiple pain. Such as skeletal muscle pain, fibromyalgia, postoperative pain, headache and neuralgia, but the results are often different, need further study.
【作者单位】：哈尔滨医科大学附属第二医院神经内科;
【基金】：黑龙江省教育厅科学技术项目(10551178) 哈尔滨医科大学附属二院博士启动基金项目
【分类号】：R749.3

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