解郁颗粒治疗慢性充血性心力衰竭伴抑郁状态患者的临床研究

发布时间：2018-05-14 18:16

  本文选题：慢性充血性心力衰竭 + 抑郁　； 参考：《山东中医药大学》2014年硕士论文

【摘要】：目的：观察解郁颗粒治疗慢性充血性心力衰竭伴抑郁状态患者的临床疗效。 方法：将60例慢性充血性心力衰竭伴抑郁患者，随机分为2组，每组各30例，两组慢性充血性心力衰竭伴抑郁患者均给以常规利尿剂、血管紧张转化酶抑制剂、β-受体阻滞剂、地高辛、醛固酮拮抗剂等药物治疗；对照组予加服黛力新（氟哌噻吨美利曲辛片，丹麦灵北制药有限公司生产），每早1片，治疗组加服解郁颗粒（潍坊市中医院自制剂）口服，一日一剂，早晚分服。观察治疗组与对照组在治疗前及治疗后2周、4周后在心衰症状、中医症候积分、BNP前体(NT-proBNP)、左室舒张末容积（LVEDD）、左室射血分数（LVEF）及HAMD量表评分等方面的差异。并经相应统计方法对结果进一步分析判定。 结果：1.在缓解中医症候积分方面，两组均有显著效果（p0.01），症候疗效方面治疗组显效率及总有效率高于对照组，但差异统计学无意义（p0.05）。2.与治疗前相比较，两组BNP前体(NT-proBNP)、左室舒张末容积（LVEDD）明显降低、左室射血分数（LVEF）明显升高，（P＜0.01）；与对照组比较，治疗4周后患者抑郁程度及生活质量明显改善，BNP前体(NT-proBNP)、左室舒张末容积（LVEDD）明显降低、左室射血分数（LVEF）明显升高（P＜0.05），治疗组优于对照组。3.两组在HAMD量表积分改善方面均有显著效果（p0.01），治疗组及对照组差异无统计学意义（p0.05）。 结论：解郁颗粒治疗慢性充血性心力衰竭伴抑郁状态患者疗效确切，，与对照组相比在HAMD量表积分改善方面两者相似，在改善患者心功能方面优于对照组，长时间服用与对照组相比无副作用。
[Abstract]:Objective: to observe the clinical effect of Jieyu granule on chronic congestive heart failure with depression. Methods: sixty patients with chronic congestive heart failure and depression were randomly divided into two groups, 30 patients in each group. The patients in both groups were given routine diuretics, angiotensin-converting enzyme inhibitors and 尾 -blockers. Digoxin, aldosterone antagonist and other drugs were used in the control group. The control group was treated with dimethylpyridine (droperthiothioate) metriaxine tablets, and the Danish Lingbei Pharmaceutical Co., Ltd., one tablet per morning. The treatment group was treated with Jieyu granule (self-made medicine of Weifang traditional Chinese Hospital), and the control group was given oral administration of digoxin, aldosterone antagonist, etc. One dose a day, sooner or later. The difference was observed between the treatment group and the control group in the symptoms of heart failure before treatment and after 2 weeks and 4 weeks after treatment. The scores of NT-proBNPN, left ventricular end-diastolic volume (LVEDDN), left ventricular ejection fraction (LVEF) and HAMD scale were compared between the treatment group and the control group in terms of BNP precursor, left ventricular end-diastolic volume (LVEDDN), left ventricular ejection fraction (LVEF) and HAMD scale. The results were further analyzed and determined by the corresponding statistical methods. The result is 1: 1. In the aspect of relieving TCM symptom integral, the two groups had significant effect, the effective rate and total effective rate of the treatment group were higher than that of the control group, but there was no significant difference between the two groups. Compared with before treatment, NT-proBNPN, left ventricular end-diastolic volume (LVEDDD) and left ventricular ejection fraction (LVEF) increased significantly in both groups (P < 0.01), and compared with control group. After 4 weeks of treatment, the degree of depression and quality of life of patients with BNP were significantly improved. NT-proBNPN, left ventricular end-diastolic volume (LVEDDD), left ventricular ejection fraction (LVEF) were significantly increased (P < 0.05), and the treatment group was superior to the control group (.3). The improvement of HAMD score in the two groups was significant (P 0.01), but there was no significant difference between the treatment group and the control group (P 0.05). Conclusion: Jieyu granule is effective in the treatment of chronic congestive heart failure with depression. Compared with the control group, the improvement of HAMD scale score is similar, and it is superior to the control group in improving the heart function of the patients. There was no side effect compared with the control group.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R541.6;R749.4

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