阿尔茨海默病患者血清S100B蛋白和抗脑抗体浓度与认知功能关系
发布时间：2018-05-17 02:14
本文选题：阿尔茨海默病 + SB蛋白 ； 参考：《中国心理卫生杂志》2017年07期
【摘要】：目的:分析阿尔茨海默病(AD)患者血清S100B、抗脑抗体(ABAb)浓度变化及其与认知功能、生活能力间的关系,探讨S100B、ABAb在AD发病机制中可能的作用。方法:研究共纳入符合美国精神障碍诊断与统计手册第IV版(DSM-IV)AD诊断的患者32例(AD组),无认知障碍老年对照40例(对照组)。采用简易智能精神状态检查量表(MMSE)、日常生活能力量表(ADL)评估所有研究对象认知功能和生活能力,采用阿尔茨海默病评定量表认知分量表(ADAS-Cog)进一步评定AD患者的认知功能;应用酶联免疫吸附法(ELISA)检测血清S100B、ABAb浓度。结果:AD组血清S100B[(0.66±0.17)μg/L vs.(0.30±0.04)μg/L]、ABAb[(1.93±0.95)U/L vs.(1.31±0.25)U/L]浓度高于对照组(均P0.01);AD组血清S100B浓度与MMSE总分负相关(r=-0.66),与ADAS-Cog总分、ADL评分呈正相关(r=0.57,r=0.53)(均P0.005);血清ABAb浓度与MMSE总分呈负相关(r=-0.57),与ADAS-Cog总分、ADL评分呈正相关(r=0.52,r=0.34)(均P0.05);AD组血清S100B与ABAb浓度正相关(r=0.51,P0.005),在对照组中并未发现此相关关系(r=0.076,P0.05)。结论:AD患者血清S100B、ABAb水平与认知损伤程度相关,提示S100B、ABAb可能在AD发病机制中起一定作用。
[Abstract]:Objective: to analyze the changes of serum S100B, anti-brain antibody ABAband their relationship with cognitive function and living ability in patients with Alzheimer's disease (AD), and to explore the possible role of S100B ABAb in the pathogenesis of AD. Methods: a total of 32 patients with AD and 40 elderly controls without cognitive impairment were enrolled in the study. The cognitive function and life ability of all the subjects were evaluated by MMSE and ADL, and the cognitive function of AD patients was further evaluated by ADAS-Cog-ADAS-Cog. Elisa was used to detect the concentration of serum S100 BX ABAb. 缁撴灉:AD缁勮娓匰100B[(0.66卤0.17)渭g/L vs.(0.30卤0.04)渭g/L],ABAb[(1.93卤0.95)U/L vs.(1.31卤0.25)U/L]娴撳害楂樹簬瀵圭収缁，
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