老年广泛性脑萎缩患者并发认知功能障碍的临床特点

发布时间：2018-05-17 13:34

本文选题：脑萎缩 + 认知功能障碍　；参考：《中国老年学杂志》2017年06期

【摘要】：目的探讨老年广泛性脑萎缩并发认知功能障碍患者的临床特点。方法老年广泛性脑萎缩患者85例,根据有无痴呆分为正常组和痴呆组。记录两组一般资料,对比两组脑梗阻、脑出血等多项慢性疾病以及血脂、血糖等15项目生化指标,分析老年广泛性脑萎缩并发认知功能障碍患者的临床特点。结果正常组患者脑梗死、脑出血以及同时伴有5种以上慢性疾病的比例明显低于痴呆组(P0.05);两组冠心病、慢性心功能不全、高血压、慢性阻塞性肺病、慢性呼吸衰竭、胃炎与消化性溃疡、功能性便秘、慢性肾功能不全、骨质疏松、胆囊炎与胆结石以及糖尿病比较无明显差异(P0.05);两组血红蛋白、血小板计数、丙氨酸转氨酶、天冬氨酸转氨酶、白蛋白、尿素、肌酐、尿酸、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖、叶酸、维生素B12以及同型半胱氨酸比较无明显差异(P0.05)。结论广泛性脑萎缩并发认知障碍患者多数伴有5种慢性病以上,年龄在80岁以上者以上临床特点可为患者的诊疗提供一定的参考依据。
[Abstract]:Objective to investigate the clinical features of senile patients with generalized brain atrophy complicated with cognitive dysfunction. Methods 85 senile patients with extensive brain atrophy were divided into normal group and dementia group. The general data of the two groups were recorded and compared with 15 items of biochemical indexes such as brain obstruction, cerebral hemorrhage and other chronic diseases, blood lipids and blood glucose. The clinical characteristics of senile patients with generalized brain atrophy complicated with cognitive dysfunction were analyzed. Results the proportion of cerebral infarction, cerebral hemorrhage and more than 5 kinds of chronic diseases in normal group was significantly lower than that in dementia group (P 0.05), coronary heart disease, chronic heart failure, hypertension, chronic obstructive pulmonary disease, chronic respiratory failure, coronary heart disease, chronic heart failure, chronic obstructive pulmonary disease, chronic respiratory failure. There was no significant difference between gastritis and peptic ulcer, functional constipation, chronic renal insufficiency, osteoporosis, cholecystitis and cholecystolithiasis and diabetes mellitus (P 0.05); hemoglobin, platelet count, alanine aminotransferase, aspartate aminotransferase, There was no significant difference in serum albumin, urea, creatinine, uric acid, total cholesterol TCU, triglyceride, low density lipoprotein cholesterol (LDL-C), fasting blood glucose, folic acid, vitamin B12 and homocysteine. Conclusion most of the patients with generalized brain atrophy complicated with cognitive impairment have more than five chronic diseases. The clinical characteristics of patients over 80 years old can provide some reference for the diagnosis and treatment of patients.
【作者单位】：上海市浦东新区周浦医院;同济大学附属东方医院神经内科;
【基金】：上海市浦东新区卫生计生委面上项目(No.PW-2015A-27)
【分类号】：R749.1

【参考文献】