儿童自闭症101例的高危因素配对分析

发布时间：2018-05-18 06:18

本文选题：自闭症 + 高危因素　；参考：《中国儿童保健杂志》2014年06期

【摘要】：目的探讨儿童自闭症发生的危险因素,为自闭症儿童的早期预防和干预提供理论基础。方法 2010年6月-2011年12月在上海市儿童医院儿童保健所就诊的儿童,经3名主治医师以上的专业医师共同确诊,符合美国精神障碍诊断和统计手册(The Diagnostic and Statistical Manual of Mental Disorders-IV,DSM-IV)诊断标准的自闭症儿童101例,同时收集正常对照儿童101例,性别和年龄分别与自闭症组匹配,由监护人填写儿童家庭社会环境调查问卷。应用t检验和χ2检验进行单因素分析,应用Logistic回归进行多因素分析。结果 Logistic回归分析进入方程的变量中,性别(OR=10.640,P0.01)、6个月前非母乳喂养(OR=2.952,P0.01)、孕期患感染性疾病(OR=2.042,P0.01)、出生时有高危因素(OR=1.189,P0.01)及父母每天陪宝宝说话或者游戏的时间(OR=0.179,P0.05)5个变量有统计学意义。结论性别为男性、6个月前非母乳喂养、母孕期患感染性疾病、出生时有高危因素是儿童患自闭症的主要危险因素,父母每天陪宝宝说话或者游戏的时间1h是保护因素。
[Abstract]:Objective to explore the risk factors of autism in children, and to provide theoretical basis for early prevention and intervention of autistic children. Methods from June 2010 to December 2011, the children in the Children's Health Center of Shanghai Children's Hospital were diagnosed by 3 or more attending physicians. 101 autistic children who met the Diagnostic and Statistical Manual of Mental Disorders-IVDSM-IVdiagnostic criteria, and 101 normal controls, matched the autism group with sex and age, respectively, according to the US Diagnostic and Statistical Manual for Mental Disorders. The guardian filled out the questionnaire of children's family social environment. T test and 蠂 2 test were used for single factor analysis and Logistic regression for multivariate analysis. Results among the variables that entered the equation by Logistic regression analysis, there were five variables: sex ORX 10.640g P0.01g, non-breast-fed ORP 2.952 P0.01a 6 months ago, pregnant women with infectious diseases (OR2.042P0.01a), high risk factors at birth (OR1.189p 0.01) and parents' daily time of talking or playing with their babies (OR 0.179p 0.05). Conclusion the main risk factors of autistic children are male, non-breast-feeding 6 months ago, infectious diseases during pregnancy, high risk factors at birth, and the protective factors are the time of parents speaking or playing games with their babies every day.
【作者单位】：上海市儿童医院;上海交通大学附属儿童医院儿童保健科;
【基金】：上海市卫生局青年基金项目(2010Y151)
【分类号】：R749.94

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