首发精神分裂症血清脂联素及代谢指标与第二代抗精神病药引发肥胖相关性研究

发布时间：2018-05-19 13:37

  本文选题：脂联素 + 第二代抗精神病药物　； 参考：《中国神经精神疾病杂志》2016年11期

【摘要】：目的通过检测首发精神分裂症患者(first-episode schizophrenic patients,FEP)服用第二代抗精神病药物(second generation antipsychotics,SGAs)8周前后的血清脂联素(adiponectin,APN)及代谢相关指标水平,探讨SGAs对首发精神分裂症患者APN的影响以及APN在SGAs引发肥胖中的作用。方法选取86例首发未服药的精神分裂症患者,及88名性别年龄相匹配的正常对照,患者组使用单一SGAs治疗8周,测定患者组治疗前、治疗8周末及对照组的体重、体质指数(body mass index,BMI)、腰臀比(waist-to-hip ratio,WHR)及空腹血糖(fasting plasma glucose,FPG)、甘油三酯(triglyceride,TG)、APN、空腹胰岛素(fasting insulin,FINS)等指标。结果患者组在治疗前APN水平低于对照组[(9.32±0.76)μg/m L vs.(10.9±0.66)μg/m L],FINS水平高于对照组[(12.68±11.70)μIU/m L vs.(6.47±2.87)μIU/m L],差异有统计学意义(P0.05)。与治疗前相比,患者组SGAs治疗8周后体重[(59.01±10.56)kg vs.(63.80±9.78)kg]、BMI[(21.74±3.57)kg/m2vs.(23.49±3.44)kg/m2]、WHR[(0.88±0.07)vs.(0.92±0.05)]、TG[(0.94±0.92)mmol/L vs.(1.63±1.08)mmol/L]和FINS水平[(12.68±11.70)μIU/m L vs.(20.27±15.02)μIU/m L]增加,差异均有统计学意义(P0.01),而患者组治疗后APN[(9.32±0.76)μg/m L vs.(8.03±0.68)μg/m L]及FPG[(5.04±1.01)mmol/L vs.(4.46±0.57)mmol/L]水平降低,差异均有统计学意义(P0.05)。在男性患者组中,基线APN水平与治疗后体重增加值呈正相关(r=0.548,P=0.005),女性患者组中该相关无统计学意义(P0.05)。结论首发精神分裂症患者在治疗前APN水平降低,SGAs可进一步降低患者APN水平;在男性患者中,基线APN水平对服药后的体重增加有预测作用。
[Abstract]:Objective to detect the serum adiponectin (APN) and metabolic related indexes of first-time episode schizophrenic patientsof patients with first-episode schizophrenia before and after 8 weeks of administration of the second generation antipsychotic drug, the second generation antipsychoticsof SGAsA, and to determine the level of serum adiponectin (APN) in patients with first-onset schizophrenia before and after 8 weeks of administration of the second-generation antipsychotic drug. To investigate the effect of SGAs on APN in patients with first-episode schizophrenia and the role of APN in SGAs induced obesity. Methods 86 patients with schizophrenia and 88 normal controls matched by sex and age were treated with single SGAs for 8 weeks. The body weight of the patients before treatment, 8 weeks after treatment and the control group were measured. Body mass index (BMI), waist-to-hip ratio (WHR), fasting plasma glucose, triglyceride (TG), fasting insulin (fins), etc. Results the level of APN in the patients group before treatment was lower than that in the control group [9.32 卤0.76 渭 g / mL vs.(10.9 卤0.66 渭 g / mL] fins level was higher than that in the control group [12.68 卤11.70 渭 IU/m L vs.(6.47 卤2.87 渭 IU/m L], the difference was statistically significant. 涓庢不鐤楀墠鐩告瘮,鎮ｈ，

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