血清血管紧张素转化酶活性在阿尔茨海默病中作用的研究

发布时间：2018-05-20 01:15

本文选题：血管紧张素转化酶 + β淀粉样蛋白　；参考：《青岛大学》2016年硕士论文

【摘要】：目的探讨血清血管紧张素转化酶(angiotensin converting enzyme,ACE)活性与认知功能的关系,进一步明确血清ACE在阿尔茨海默病(Alzheimer,s disease,AD)中的作用及与其严重程度的关系。方法纳入受试者167例,将其分为对照组(39例),遗忘型轻度认知障碍(amnestic mild cognitive impairment,a MCI)(45例)、轻度AD组(21例)及中重度AD组(62例),并分析其ACE活性及Aβ1-40/42水平。结果AD组与a MCI组(P=0.047)及对照组(P=0.01)比较差异均具有显著性,同时中重度AD组ACE明显高于a MCI组(P=0.04)及对照组(P=0.01)。AD病人血清Aβ1-40有增加趋势,血清Aβ1-42有早期升高,晚期下降趋势,但无统计学差异(P0.05)。排除性别、年龄及受教育年的影响,与对照组相比,血清ACE活性每增加200 U/L,发生AD的优势增加37%,是升高前的1.37倍(OR 1.37,95%CI 1.00~1.87;P=0.05)。将ACE相关因素纳入多重线性回归分析显示,仅Aβ1-40水平及Aβ1-42水平对ACE活性的影响有统计学意义(P0.00),且ACE活性总变异的92%与Aβ1-40水平与Aβ1-42水平有关,Aβ1-42水平对ACE活性的影响较大。AD组血清ACE活性与MMSE及其亚项定向力和即刻回忆呈负相关(r0,P0.05),且对定向力影响较大。但非AD组无此相关性(P0.05)。结论血清ACE活性可能是AD发展的潜在危险因素,前者可能成为AD疾病状态特别是中重度AD的潜在生物学标志物;本研究支持a MCI病人服用ACE药物预防AD的发病,AD病人服用ACEI药物延缓其认知功能减退。
[Abstract]:Objective to investigate the relationship between the activity of serum angiotensin converting (converting) and cognitive function, and to further clarify the role of serum ACE in Alzheimer's disease (AD) and its relationship with its severity. Methods 167 subjects were divided into control group (39 cases), amnestic mild cognitive impairmenta (MCI)(45) group (21 cases) and moderate and severe AD group (62 cases). ACE activity and A 尾 1-40 / 42 level were analyzed. Results there were significant differences between AD group and a MCI group (P < 0.047) and control group (P < 0.01). At the same time, the ACE in moderate and severe AD group was significantly higher than that in a MCI group (P 0.04). The serum A 尾 1-40 in patients with AD and control group was increased, and A 尾 1-42 was increased in early stage and decreased in late stage. But there was no statistical difference (P 0.05). Excluding the influence of sex, age and years of education, compared with the control group, for every 200UL increase in serum ACE activity, the predominance of AD was increased 37 times, which was 1.37 times as much as that before the increase. The factors related to ACE were included in multiple linear regression analysis. Only the levels of A 尾 1-40 and A 尾 1-42 had significant effects on the activity of ACE, and 92% of the total variation of ACE activity was related to the level of A 尾 1-40 and A 尾 1-42, and the level of A 尾 1-42 had a greater effect on the activity of ACE. Immediate recall was negatively correlated with r0. 05, and had a significant effect on orientation. But no correlation was found in non-AD group (P 0. 05). Conclusion Serum ACE activity may be a potential risk factor for the development of AD, and the former may be a potential biomarker of AD disease, especially moderate and severe AD. This study supports the prevention of AD with ACE in patients with a MCI and the delay of cognitive impairment with ACEI in AD patients.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R749.16

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