艾司西酞普兰与盐酸帕罗西汀治疗抑郁症伴广泛性焦虑的随机对照研究

发布时间：2018-05-22 17:28

本文选题：抑郁症 + 广泛性焦虑　；参考：《华中科技大学》2012年硕士论文

【摘要】：目的：探讨艾司西酞普兰与帕罗西汀对抑郁症伴广泛性焦虑的疗效和安全性。方法：105例抑郁症伴广泛性焦虑的患者随机分为艾司西酞普兰组（实验组）和盐酸帕罗西汀组（对照组），分别给与艾司西酞普兰和盐酸帕罗西汀治疗，疗程6周。以汉密尔顿抑郁量表（HAMD)和汉密尔顿焦虑量表(HAMA)评定疗效。结果：治疗1周后，实验组HAND评分20.35、HAMA评分16.05，对照组HAND评分27.31、HAMA评分19.55，，实验组评分较对照组显著下降（P0.05）；两组治疗6周后，艾司西酞普兰组（实验组）HAND评分8.26、HAMA评分6.90，盐酸帕罗西汀组（对照组）HAND评分9.64、HAMA评分7.92，均较治疗前显著下降（P0.05)。结论：艾司西酞普兰治疗抑郁症伴广泛性焦虑安全、有效；与盐酸帕罗西汀比较，起效更快，副反应更少。
[Abstract]:Objective: to investigate the efficacy and safety of Escitalopram and paroxetine in the treatment of depression with generalized anxiety. Methods 105 patients with depression with generalized anxiety were randomly divided into two groups: the estalcitalopram group (experimental group) and paroxetine hydrochloride group (control group), which were treated with escitalopram and paroxetine hydrochloride for 6 weeks. The efficacy was evaluated by Hamilton Depression scale (Hamd) and Hamilton anxiety scale (Hama). Results: after one week of treatment, the HAND score of the experimental group was 20.35 Hama 16.05, the HAND score of the control group was 27.31 Hama 19.55, the score of the experimental group was significantly lower than that of the control group (P 0.05), and after 6 weeks of treatment, the scores of the two groups were significantly lower than that of the control group. The Hama score of Hama was 6.90 in the experimental group and 7.92 in the paroxetine hydrochloride group, which was significantly lower than that before treatment. Conclusion: Escitalopram is safe and effective in the treatment of depression with generalized anxiety, and has faster onset and less side effects than paroxetine hydrochloride.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.4

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