血尿酸水平与轻度认知功能障碍关系的研究

发布时间：2018-05-24 06:26

本文选题：轻度认知功能障碍 + 尿酸　；参考：《中国卫生检验杂志》2014年14期

【摘要】：目的探讨轻度认知功能障碍(MCI)患者的认知功能和血尿酸(UA)水平的关系。方法采用病例对照研究,选取139例MCI患者作为病例组,213名健康人作为对照组,用全自动生化分析仪检测MCI患者和对照组血清尿酸、血糖及血脂水平。结果 MCI组血尿酸水平(311.47±82.71)μmol/L高于对照组(285.05±77.03)μmol/L,MCI组总胆固醇[(5.57±1.02)mmol/L比(5.33±0.97)mmol/L]和低密度脂蛋白胆固醇[(3.21±0.80)mmol/L比(3.03±0.76)mmol/L]水平也高于对照组,差异有统计学意义(P=0.003;P=0.027;P=0.041)。空腹血糖[(5.79±1.67)mmol/L比(5.68±1.46)mmol/L]、三酰甘油[(1.81±0.98)mmol/L比(1.66±1.21)mmol/L]和高密度脂蛋白胆固醇[(1.36±0.30)mmol/L比(1.38±0.30)mmol/L]水平在两组中差异无统计学意义(P=0.520;P=0.222;P=0.608)。logistic回归分析显示,尿酸是MCI的独立危险因素(P=0.027,OR=1.004,95%CI:1.000~1.007)。结论 MCI患者尿酸水平升高,高尿酸水平可能与认知功能障碍相关。
[Abstract]:Objective to investigate the relationship between cognitive function and serum uric acid (UAA) level in patients with mild cognitive impairment (MCI). Methods in a case-control study, 139 MCI patients were selected as the case group and 213 healthy persons as the control group. The serum uric acid, blood glucose and blood lipid levels in the patients with MCI and the control group were measured by automatic biochemical analyzer. Results the serum uric acid level in MCI group was 311.47 卤82.71 渭 mol/L higher than that in control group (285.05 卤77.03) 渭 mol / L MCI group. The levels of total cholesterol [5.57 卤1.02)mmol/L vs 5.33 卤0.97)mmol/L] and low density lipoprotein cholesterol [3.21 卤0.80)mmol/L vs 3.03 卤0.76)mmol/L] in MCI group were also higher than those in control group. Fasting blood glucose [5.79 卤1.67)mmol/L vs 5.68 卤1.46)mmol/L], triacylglycerol [1.81 卤0.98)mmol/L vs 1.66 卤1.21)mmol/L] and high-density lipoprotein cholesterol [1.36 卤0.30)mmol/L vs 1.38 卤0.30)mmol/L] were not significantly different between the two groups. Logistic regression analysis showed that uric acid was an independent risk factor for MCI. Conclusion the level of uric acid in MCI patients is higher, and the high uric acid level may be related to cognitive impairment.
【作者单位】：北京医院北京老年医学研究所;
【基金】：国家自然科学基金项目(30400361) 北京医院院级课题(BJ-2012-52)
【分类号】：R749.16

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