血管性痴呆大鼠肾素-血管紧张素-醛固醇系统的动态变化

发布时间：2018-05-26 17:09

  本文选题：肾素-血管紧张素-醛固酮系统 + 脑缺血　； 参考：《中国老年学杂志》2017年14期

【摘要】：目的观察血管性痴呆(VD)大鼠血浆和脑组织肾素-血管紧张素(Ang)-醛固酮(ALD)系统(RAAS)的动态变化。方法经水迷宫筛选出学习记忆能力正常雄性SD大鼠80只随机分入正常组、模型组(1 d)、模型组(3 d)、模型组(7 d)、模型组(14 d)、模型组(21 d)、模型组(30 d),按照设计时间梯度采用不同时点分别结扎左、右双侧颈总动脉法制备VD模型大鼠。观察正常组和模型组(30 d)的空间学习记忆情况,检测血浆、脑皮质及海马肾素活性、AngⅡ、ALD水平以及脑组织病理学检查。结果模型组(30 d)和正常组水迷宫数据比较差异显著(P0.05),说明模型制备成功。血浆、皮质及海马中肾素活性、AngⅡ及ALD的水平模型组随时间增加其水平总体呈现增高趋势,但脑组织与血浆水平变化无线性相关性;脑组织光镜下病理学观察发现,随缺血时间增加脑皮质及海马损伤有加重趋势。结论 RAAS在脑缺血的发生发展中有着重要作用。
[Abstract]:Objective to observe the dynamic changes of plasma and brain tissue renin-angiotensin angiotensin-aldosterone (ALD) system in rats with vascular dementia (VD). Methods 80 male Sprague-Dawley rats with normal learning and memory abilities were randomly divided into normal group by water maze. The VD model rats were established by ligating left and right common carotid arteries at different time points according to the design time gradient in model group, and model group, respectively, for 1 d, 3 d, 7 d, 14 d, 21 d, and 30 d respectively, according to the design time gradient, the left and right common carotid arteries were ligated at different time points. The spatial learning and memory were observed in normal group and model group at 30 days. The levels of Ang 鈪，

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