帕罗西汀片治疗产后抑郁的临床研究

发布时间：2018-05-26 20:58

本文选题：帕罗西汀片 + 产后抑郁　；参考：《中国临床药理学杂志》2017年01期

【摘要】：目的观察帕罗西汀片对产后抑郁患者的临床疗效。方法将61例产后抑郁患者随机分为对照组30例和试验组31例。对照组口服马普替林片,初始剂量为50 mg·d~(-1),14 d内剂量根据耐受情况进行剂量调整,最大剂量为250 mg·d~(-1),每日2次。试验组口服帕罗西汀片,初始剂量为10 mg·d~(-1),14 d内剂量增加至40 mg·d~(-1),根据耐受情况进行剂量调整,最大剂量为60 mg·d~(-1),每日2次。2组均持续用药6周。比较2组患者的临床疗效、血清C-反应蛋白及雌激素水平。结果试验组的临床总有效率96.77%(30/31例),对照组为76.67%(23/30例,P0.05)。治疗后,试验组C-反应蛋白为(5.57±0.65)ng·mL~(-1),对照组为(8.94±1.63)ng·mL~(-1)(P0.05)。试验组雌二醇水平为(228.57±39.87)pg·mL~(-1),对照组为(186.46±36.56)pg·mL~(-1);试验组促卵泡生成素为(75.01±13.01)pg·mL~(-1),对照组为(60.13±9.81)pg·mL~(-1);试验组促黄体生成素为(46.41±9.67)pg·mL~(-1),对照组为(33.46±7.37)pg·mL~(-1)(P0.05)。试验组出现震颤1例,便秘1例,药物不良反应发生率为6.45%(2/31例);对照组出现轻度口干1例,便秘2例,药物不良反应发生率为10.00%(3/30例),2组药物不良反应发生率相比,差异无统计学意义(P0.05)。结论帕罗西汀治疗产后抑郁的临床疗效确切,有利于雌激素水平调节,并能有效地减轻产后抑郁程度,安全性高。
[Abstract]:Objective to observe the clinical effect of paroxetine tablets on postpartum depression. Methods 61 patients with postpartum depression were randomly divided into control group (n = 30) and trial group (n = 31). The control group was treated with maprotiline tablets. The initial dose was 50mg / d and the dosage was adjusted according to the tolerance condition within 14 days. The maximum dose was 250 mg / d, twice a day. The experimental group took paroxetine tablets orally, the initial dose was 10 mg / d and the dosage was increased to 40 mg / d within 14 days. The maximum dose of paroxetine was 60 mg / d ~ (-1) and the dosage was 60 mg / d / d for 6 weeks. The clinical efficacy, serum C-reactive protein and estrogen levels were compared between the two groups. Results the total clinical effective rate of the trial group was 96.77 / 30 / 30 cases, and that of the control group was 76.6767 / 23 / 30 cases (P 0.05). After treatment, the C- reactive protein in the experimental group was 5.57 卤0.65)ng mLP-1, while in the control group it was 8.94 卤1.63)ng mLL- 1 (P0.05). The levels of estradiol in the experimental group were 228.57 卤39.87)pg mLL-1 and those in the control group were 186.46 卤36.56)pg mLL-1, respectively. The levels of follicle stimulating hormone in the experimental group were 75.01 卤13.01)pg mLL-1, and in the control group were 60.13 卤9.81)pg mLL-1, and luteinizing hormone were 46.41 卤9.67)pg mL-1, and 33.46 卤7.37)pg mLL-1, respectively, in the experimental group and in the control group were 33.46 卤7.37)pg mLL-1 and 33.46 卤7.37)pg mLL- 1, respectively, and in the control group, the levels of estradiol were 75.01 卤13.01)pg mLL-1 and 60.13 卤9.81)pg mLL-1, respectively. There were 1 case of tremor and 1 case of constipation in the trial group, and the incidence of adverse drug reaction was 6.4545 / 2 / 31 cases, while in the control group, there were 1 case of mild dry mouth, 2 cases of constipation and 10.00% of 30 cases of constipation. The difference was not statistically significant (P 0.05). Conclusion paroxetine is effective in the treatment of postpartum depression, which is beneficial to the regulation of estrogen level, and can effectively reduce the degree of postpartum depression.
【作者单位】：上海市周浦医院妇产科;
【基金】：上海市浦东新区重点学科基金资助项目(PWZx2014--18)
【分类号】：R749.4

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