老年抑郁症DTI和TDI研究

发布时间：2018-05-27 06:19

本文选题：老年抑郁症 + 弥散张量成像　；参考：《中国医学计算机成像杂志》2017年04期

【摘要】：目的:通过弥散张量成像和纤维束密度成像探讨老年抑郁症患者脑白质的完整性。方法:25例老年抑郁症患者为实验组,20名健康老年人为对照组,进行3.0T磁共振弥散张量成像(DTI)和纤维束密度成像(track-density imaging,TDI),并计算其双侧额叶、双侧颞叶、双侧扣带回及胼胝体膝部、压部白质的各向异性分数(FA)和纤维束密度值(track density,TD),分别比较两组数据差异。结果:与对照组相比,实验组左侧额叶、左侧颞叶、双侧扣带回前部及胼胝体膝部FA值显著降低(P0.05),双侧额叶、双侧颞叶、双侧扣带回前部及胼胝体膝部纤维束密度值显著降低(P0.05)。结论:老年抑郁症患者多发脑区白质完整性破坏,TDI为高分辨率成像技术,可以清晰显示解剖结构,纤维束密度值可能较各向异性分数更敏感的发现老年抑郁症患者的脑白质异常。
[Abstract]:Objective: to investigate the integrity of white matter in elderly patients with depression by diffusion Zhang Liang imaging and fiber bundle density imaging. Methods Twenty and twenty healthy elderly patients with depression in the experimental group were treated with 3.0T magnetic resonance diffusion Zhang Liang imaging (DTI) and fiber bundle density imaging (TDI). The bilateral frontal lobe, bilateral temporal lobe, bilateral cingulate gyrus and the genu of corpus callosum were calculated. The anisotropic fraction of compressed white matter (FAA) and the fiber bundle density (TDX) were compared between the two groups. Results: compared with the control group, the FA values of left frontal lobe, left temporal lobe, bilateral anterior cingulate gyrus and genu of corpus callosum were significantly lower in the experimental group than those in the control group, and the density of fiber bundle in bilateral frontal lobe, bilateral temporal lobe, bilateral cingulate gyrus and genu of corpus callosum was significantly lower than that in control group (P 0.05). Conclusion: TDI is a high resolution imaging technique and can clearly display the anatomical structure of multiple brain areas in elderly patients with depression. Fiber bundle density may be more sensitive than anisotropic scores to detect white matter abnormalities in elderly patients with depression.
【作者单位】：上海交通大学附属第六人民医院放射科;
【基金】：国家自然科学基金No.81471656 上海市自然基金NO.14ZR1432100 上海市人才发展基金NO.201555~~
【分类号】：R445.2;R749.4

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