双相情感障碍中心境稳定剂的处方方式调查

发布时间：2018-05-29 23:47

本文选题：双相情感障碍 + 心境稳定剂　；参考：《中国神经精神疾病杂志》2014年04期

【摘要】：目的了解河北省双相情感障碍患者心境稳定剂的处方方式,并探讨其相关因素。方法采用自编的患者药物使用调查表及不良反应量表(treatment emergent symptom scale,TESS),对河北省11个地市的39家精神疾病专科医院或综合医院精神科中518例双相情感障碍患者进行处方方式调查。结果 397例(76.3%)患者接受心境稳定剂治疗,主要是丙戊酸钠、碳酸锂及丙戊酸镁。联合抗精神病药、抗抑郁药或抗焦虑药的联合治疗占94.5%(375/397)。抑郁发作(54.5%)及混合发作(66.7%)时应用心境稳定剂的频率低于躁狂发作(83.9%),差异均具有统计学意义(均P0.009)。应用心境稳定剂的患者中不良反应发生率为48.1%(191/397),以便秘、体重增加、嗜睡、静坐不能、震颤及口干为常见。Logistic回归分析显示,以症状缓解期为参照,目前疾病发作类型中抑郁发作的患者应用心境稳定剂的频率较低(OR=2.549,P=0.018)。结论双相情感障碍中心境稳定剂的应用以丙戊酸盐及碳酸锂为主,抑郁发作时应提高心境稳定剂的应用频率。
[Abstract]:Objective to investigate the prescription of mood stabilizer in patients with bipolar disorder in Hebei province and its related factors. Methods 518 patients with bipolar affective disorder in 39 psychiatric hospitals or general hospitals in 11 cities of Hebei Province were investigated with self-designed drug use questionnaire and adverse reaction scale (ADR). Results 397 patients were treated with mood stabilizer, mainly sodium valproate, lithium carbonate and magnesium valproate. Combined therapy with antipsychotics, antidepressants, or antianxiety drugs accounted for 94.555 / 397g. The frequency of using mood stabilizer was lower than that of manic attack (P 0.009). The incidence of adverse reactions in patients with mood stabilizer was 48.1 / 3970.Constipation, weight gain, lethargy, sedentary inability, tremor and dry mouth were the common. Logistic regression analysis showed that the symptom remission period was the reference. At present, the frequency of using mood stabilizer is lower in patients with depression attack. Conclusion in bipolar affective disorder, valproate and lithium carbonate are the main use of mood stabilizer, and the frequency of application of mood stabilizer should be increased during depression.
【作者单位】：河北省第六人民医院;
【基金】：河北省卫生厅青年科技课题(编号:20130074)
【分类号】：R749.4

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