不同危险因素与轻度认知功能障碍亚型关系的研究

发布时间：2018-05-30 06:08

本文选题：轻度认知功能障碍 + 分型　；参考：《青岛大学》2012年硕士论文

【摘要】：目的探讨遗忘型、非遗忘型轻度认知功能障碍患者不同危险因素的差异。方法收集2011年1月至2011年9月于青岛市市属三家三级医院神经内科住院的65-75岁轻度认知功能障碍患者的健康资料,应用简易智能状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)全面评价患者的认知功能,采用Petersen标准将轻度认知功能障碍的病人分成遗忘型(aMCI)和非遗忘型(non-aMCI)两组,比较两组患者的不同危险因素。结果单变量分析显示,aMCI和non-aMCI两组患者的糖尿病、高胆固醇、MoCA评分存在显著差异(P0.05)。多变量logistic回归分析显示,aMCI组患者MoCA评分(OR1.081,95%CI1.001-1.204；P=0.040)明显低于non-aMCI组；non-aMCI组糖尿病(OR0.258,95%C10.096-0.695；P=0.009)比例明显高于aMCI组：aMCI组胆固醇(OR13.345,95%CI1.127-158.085；P=0.011)水平明显高于non-aMCI组,且高胆固醇为aMCI的独立危险因素。结论不同的危险因素对aMCI、non-aMCI两组患者所施加的效应不同。
[Abstract]:Objective to explore the difference of risk factors between amnesia and non amnesia in patients with mild cognitive impairment. Methods from January 2011 to September 2011, the health data of patients with mild cognitive impairment aged 65 to 75 years in Department of Neurology, three Grade III Hospitals of Qingdao City were collected. The patients with mild cognitive impairment were divided into amnesia group and non-amnesia non-MCI group by using the simple Mental State Checklist (MMSE) and the Montreal Cognitive Assessment scale (MOCA). The patients with mild cognitive impairment were divided into two groups: amnesia group and non-amnesia group. Different risk factors were compared between the two groups. Results the univariate analysis showed that there was a significant difference in the score of high cholesterol moca between the two groups (P 0.05). Multivariate logistic regression analysis showed that the MoCA score of MCI group was significantly higher than that of non-aMCI group (CI 1.001-1.204 P0.040), significantly lower than that of non-aMCI group (0.258, 950.096-0.695 P0. 009). It was significantly higher than that of aMCI group (1.127-158.085), and high cholesterol was the independent risk factor of aMCI. Conclusion the effects of different risk factors on patients with aMCI non-aMCI are different.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.1

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