阿尔茨海默病患者血清脂联素水平与认知功能的相关性

发布时间：2018-06-02 23:34

本文选题：阿尔茨海默病 + 脂联素　；参考：《南方医科大学学报》2017年04期

【摘要】：目的探讨阿尔茨海默病患者血清脂联素水平及其与认知功能的关系。方法采用病例对照研究方法,选取90例临床诊断很可能的阿尔茨海默病(AD)患者为AD组,并根据MMSE评分,将AD组分成轻、中、重3个亚组,选取年龄及性别相匹配的非AD健康体检者90例为对照组;通过酶联免疫吸附法分别检测AD组和对照组血清脂联素的水平。结果(1)AD组血清脂联素水平显著低于对照组,差异有统计学意义(P0.05);AD组3个亚组的血清脂联素水平分别与对照组比较:中、重度AD组血清脂联素水平和对照组比较差异有统计学意义(P0.05),轻度AD组血清脂联素和对照组比较差异无明显统计学意义(P0.05);AD组3个亚组之间的血清脂联素水平两两比较差异有统计学意义(P0.05);(2)AD患者血清脂联素水平与MMSE评分的相关分析示:血清脂联素水平与MMSE得分呈正相关性(r=0.683,P0.001)。结论阿尔茨海默病患者血清脂联素水平降低;阿尔茨海默病患者血清脂联素水平可以反映认知功能损害的程度。
[Abstract]:Objective to investigate the relationship between serum adiponectin level and cognitive function in patients with Alzheimer's disease. Methods A case-control study was carried out in 90 patients with Alzheimer's disease (AD). According to the MMSE score, the AD group was divided into three subgroups: mild, moderate and severe. The serum adiponectin levels in AD group and control group were detected by Elisa. Results the serum adiponectin level in AD group was significantly lower than that in control group (P 0.05), and the serum adiponectin level in AD group was significantly lower than that in control group. The serum adiponectin level in severe AD group was significantly different from that in control group (P 0.05). There was no significant difference in serum adiponectin level between mild AD group and control group. There was no significant difference in serum adiponectin level between three subgroups of AD group. The correlation analysis between serum adiponectin level and MMSE score showed that the serum adiponectin level was positively correlated with MMSE score. Conclusion Serum adiponectin levels in patients with Alzheimer's disease are lower than those in patients with Alzheimer's disease, and the level of adiponectin in patients with Alzheimer's disease can reflect the degree of cognitive impairment.
【作者单位】：中南大学湘雅三医院神经内科;长沙市第一医院神经医学中心;湖南省脑科医院神经内三科;
【基金】：湖南省科技厅重点研发计划(2015SF2029-2,2016JC2052) 长沙市第一医院院级课题(Y2016-05) 中南大学湘雅三医院新湘雅人才工程“至善领跑计划”(20150305)
【分类号】：R749.16

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