心律失常射频消融术后焦虑状态患者的静息态MRI低频振幅分析

发布时间：2018-06-05 01:07

本文选题：射频消融 + 焦虑症　；参考：《中国介入影像与治疗学》2017年08期

【摘要】：目的采用低频振幅(ALFF)观察心律失常射频消融术后出现焦虑状态患者的全脑功能活动。方法收集符合纳入标准的26例心律失常射频消融术(RFCA)后焦虑状态患者作为RFCA组,纳入同期年龄、性别相匹配的26名健康志愿者作为正常对照组,2组均行fMRI,对2组有差异脑区的ALFF进行双样本t检验,提取有差异的脑区与汉密尔顿焦虑量表评分进行偏相关分析。结果与正常对照组相比,RFCA组左侧颞中回、右侧壳核、左侧杏仁核ALFF增高,左侧前额叶背外侧皮层(DLPFC)、右侧楔前叶、左侧额中叶、右侧枕中叶ALFF减低差异有统计学意义(Alphasim校正,P0.01)。左侧DLPFC的ALFF值与HAMA评分呈负相关(r=-0.872,P=0.013)。结论心律失常射频消融术后焦虑状态患者在静息状态下存在脑功能的异常,ALFF有助于为该疾病的发病机制提供更多证据。
[Abstract]:Objective to observe the global brain function of patients with anxiety after radiofrequency ablation of arrhythmia. Methods 26 patients with anxiety after radiofrequency ablation of arrhythmia were collected as RFCA group, and were included in the same age group. Twenty-six healthy volunteers matched by sex were treated with fMRI in both groups as normal control group. The ALFF of different brain regions in both groups were tested by double sample t-test, and partial correlation analysis was carried out between the different brain areas and Hamilton anxiety scale score. Results compared with the control group, the ALFF in left middle temporal gyrus, right putamen nucleus and left amygdaloid nucleus were increased, and the decrease of ALFF in the left dorsolateral prefrontal cortex, right anterior wedge, left middle frontal lobe and right occipital middle lobe was significantly lower than that in the control group (P 0.01). The ALFF value of left DLPFC was negatively correlated with HAMA score. Conclusion there is abnormal brain function in patients with anxiety after radiofrequency ablation of arrhythmia. ALFF is helpful to provide more evidence for the pathogenesis of the disease.
【作者单位】：深圳市第二人民医院深圳大学第一附属医院放射科;
【分类号】：R445.2;R541.7;R749.72

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