帕金森病和阿尔茨海默病患者脑内血管周围间隙扩大的差异

发布时间：2018-06-05 17:55

本文选题：阿尔茨海默病 + 帕金森病　；参考：《临床放射学杂志》2017年09期

【摘要】：目的初步分析帕金森病(PD)和阿尔茨海默病(AD)基底节区及半卵圆中心区血管周围间隙扩大(EPVS)的情况及两者是否存在差异。方法 67例AD患者,平均年龄(70.57±10.44)岁,男32例,女35例;58例PD患者,平均年龄(66.96±8.45)岁,男28例,女30例;60名年龄、性别相匹配的健康老年人,平均年龄(69.83±7.26)岁,男28名,女32名,被纳入本次研究。通过观察MRI T_2WI及T_2FLAIR图像,分别计数各组基底节区及半卵圆中心区EPVS的数目并进行4级评分。采用SPSS 17.0软件进行统计学处理,计数资料比较采用单因素方差分析,组间均数比较采用t检验,等级资料用Kruskal-Wallis及Kolmogorov-Smirnov Z检验分析组间差异。应用Spearman相关分析EPVS与简易精神状态检查量表(MMSE)评分之间的相关性。P0.05为差异有统计学意义。结果三组间基底节、半卵圆中心区EPVS评分均有统计学意义(H值分别为17.91,46.28,P均0.01)。与正常对照组比较,AD组基底节区的EPVS评分差异有统计学意义(Z=1.939,P0.001),PD组与对照组及AD组的EPVS评分差异均无统计学差异(Z分别=1.314,0.83,P均0.05);在半卵圆中心区域,AD组及PD组分别与正常对照组比较EPVS评分差异均有统计学意义(Z=2.786,Z=1.518,P0.05),除此之外,PD组与AD组间评分差异也有统计学意义(Z=1.585,P0.01)。三组间基底节区及半卵圆中心区EPVS累计得分符合正态分布,AD组总EPVS评分(4.38±1.34)显著高于PD组(3.55±1.17)(P0.01)。65岁时,AD组与PD组两者间EPVS评分差异无统计学意义(P0.05),但AD组及PD组EPVS评分均高于正常对照组(P均0.01);65~75岁时,三组间EPVS评分两两比较差异均有统计学意义(P0.05);75岁时,三组间EPVS评分两两比较差异均有统计学意义(P均0.01)。结论 EPVS是PD和AD患者脑内的微血管改变,而且PD和AD脑内EPVS分布也有所区别,且随着年龄的增长,两者间的差异性逐渐增加。
[Abstract]:Objective to analyze the extent of enlargement of perivascular space in basal ganglia and central semi-oval region of Parkinson's disease (PD) and Alzheimer's disease (AD) and whether there are differences between them. Methods Sixty-seven patients with AD, with an average age of 70.57 卤10.44 years, 32 males and 35 females, with an average age of 66.96 卤8.45 years, 28 males and 30 females, with an average age of 69.83 卤7.26 years, 28 males and 32 females, were enrolled in this study. Was included in this study. By observing the MRI T_2WI and T_2FLAIR images, the number of EPVS in the basal ganglia and the central semi-oval region in each group were counted and graded in 4 grades. SPSS 17.0 software was used for statistical processing. The counting data were compared by single factor ANOVA, the mean of group was analyzed by t test, and the difference between groups was analyzed by Kruskal-Wallis and Kolmogorov-Smirnov Z test. Using Spearman correlation analysis, the correlation between EPVS and MMSE score was statistically significant. Results the EPVS scores of basal ganglia and central semi-oval area in the three groups were significantly higher than those in the control group (P < 0.01). There was no significant difference in EPVS score between AD group and control group and AD group (P < 0.05), and in AD group and PD group, there was no significant difference between AD group and AD group in basal ganglia score of basal ganglia, and there was no significant difference in EPVS score between AD group and control group and AD group, and there was no significant difference in EPVS score between AD group and PD group in central region of semicircle, and there was no significant difference in EPVS score between AD group and control group and AD group (P < 0.05). There were significant differences in EPVS score between normal control group and control group. In addition, there was significant difference in EPVS score between PD group and AD group. The cumulative EPVS scores of basal ganglia and centroid ovale in AD group (4.38 卤1.34) were significantly higher than those in AD group (3.55 卤1.17)(P0.01).65 years old) and PD group (P 0.05), but EPVS scores in AD group and PD group were not significantly different. All of them were higher than those in the normal control group (P < 0.01) at the age of 65 ~ 75 years. There were significant differences in EPVS scores between the three groups at 75 years old, and there were significant differences in EPVS scores between the three groups (P < 0.01). Conclusion EPVS is a microvascular change in the brain of PD and AD patients, and the distribution of EPVS in PD and AD is different, and the difference between PD and AD increases with age.
【作者单位】：大连医科大学附属第一医院放射科;
【分类号】：R445.2;R742.5;R749.16

【相似文献】