白介素1β基因多态性与新疆维吾尔族人群抑郁症的相关性研究

发布时间：2018-06-07 11:30

本文选题：抑郁症 + 白介素β　；参考：《中国全科医学》2014年30期

【摘要】：背景维吾尔族有独特的遗传背景,其抑郁症易患基因表达可能与其他民族存在着很大的差异。细胞因子在抑郁症的发病机制中起重要作用,细胞因子基因多态性可能通过影响细胞因子的产生导致神经内分泌的改变从而引起抑郁症状。寻找白介素1β(IL-1β)基因中可能具有抑郁症易患性的单核苷酸多态性(SNP)位点,探讨维吾尔族抑郁症潜在致病基因的差异,为寻求诊断、个体化治疗和预防提供更广的思路。目的探讨IL-1β基因rs1143634和rs3136558位点多态性与新疆维吾尔族抑郁症的相关性。方法选取2012年1月—2013年10月在新疆医科大学第一附属医院心理医学科住院的维吾尔族抑郁症患者100例为抑郁症组,体检中心无精神疾病史、无精神病药物治疗史、无物质滥用史、无神经系统疾病或损伤史者120例为对照组,采用聚合酶链反应-限制性片段长度多态性方法检测受试者IL-1β基因rs1143634和rs3136558位点基因型和等位基因频率分布情况。结果抑郁症组和对照组rs1143634位点和rs3136558位点CC、CT和TT基因型分布比较,差异无统计学意义(P0.05);C和T等位基因频率比较,差异亦无统计学意义(P0.05)。结论 IL-1β基因rs1143634和rs3136558位点基因多态性与新疆维吾尔族抑郁症的发生无明显相关性。
[Abstract]:Background the Uygur nationality has a unique genetic background and its gene expression of depression predisposition may be very different from that of other nationalities. Cytokines play an important role in the pathogenesis of depression. Cytokine gene polymorphisms may lead to neuroendocrine changes and depressive symptoms by affecting cytokines production. To search for the SNPs of the IL-1 尾) gene, which may be susceptible to depression, to explore the difference of the potential pathogenic genes of depression in Uygur nationality, and to provide a broader way of thinking for seeking diagnosis, individualized treatment and prevention. Objective to investigate the association of IL-1 尾 gene rs1143634 and rs3136558 polymorphism with Xinjiang Uygur depression. Methods from January 2012 to October 2013, 100 patients with depression of Uygur nationality who were hospitalized in Department of Psychiatry, first affiliated Hospital of Xinjiang Medical University were selected as depression group. The genotypes and alleles of IL-1 尾 gene rs1143634 and rs3136558 loci were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 120 patients with no history of substance abuse and no history of nervous system disease or injury. Results the genotypes of rs1143634 and rs3136558 loci in depression group were not significantly different from those in control group (P 0.05), and there was no significant difference in the frequency of C and T alleles between depression group and control group (P 0.05). Conclusion the polymorphism of rs1143634 and rs3136558 loci of IL-1 尾 gene is not associated with the occurrence of depression in Xinjiang Uygur nationality.
【作者单位】：新疆医科大学第一附属医院心理医学科;
【基金】：新疆维吾尔自治区自然科学基金资助项目(2011211A081)
【分类号】：R749.42

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