双相情感障碍血清尿酸水平研究

发布时间：2018-06-09 04:36

本文选题：双相情感障碍 + 躁狂发作　；参考：《中国神经精神疾病杂志》2016年01期

【摘要】：目的探讨双相情感障碍患者血清尿酸(uric acid,UA)水平变化及其临床意义。方法纳入双相情感障碍患者126例(躁狂发作77例,抑郁发作49例)、首发精神分裂症患者69例和正常对照126名,测定其血清UA水平,并采用杨氏躁狂量表(Young mania rating scale,YMRS)和汉密尔顿抑郁量表(Hamilton depressionscale,HAMD)评定双相情感障碍患者症状。结果双相情感障碍组血清UA水平[(349.34±107.21)μmol/L]高于精神分裂症组[(319.71±84.48)μmol/L]和对照组[(280.94±71.90)μmol/L],差异有统计学意义(P0.01);躁狂发作患者UA水平高于抑郁发作患者[(366.45±104.01)μmol/L vs.(322.45±107.69)μmol/L],且二者均高于对照组(P0.01);双相情感障碍患者中是否使用精神科药物的亚组间UA水平无统计学差异(P0.05)。双相情感障碍患者血清UA水平与YMRS、HAMD分数线性相关均无统计学意义(P0.05)。结论双相情感障碍患者血清UA水平升高,血清UA水平升高可能是双相情感障碍的一个生物标记物。
[Abstract]:Objective to investigate the changes and clinical significance of serum uric acid acidosis UAA in patients with bipolar disorder. Methods Serum UA levels were measured in 126 patients with bipolar disorder (77 mania, 49 depression, 69 first-episode schizophrenia and 126 normal controls). The symptoms of bipolar affective disorder were assessed by Young mania rating scale and Hamilton Depression scale. Results the serum UA level in bipolar disorder group [349.34 卤107.21 渭 mol / L] was higher than that in schizophrenia group [319.71 卤84.48 渭 mol / L] and control group [280.94 卤71.90 渭 mol / L], the level of UA in bipolar disorder group was higher than that in depression group (366.45 卤104.01) 渭 mol / L vs.(322.45 卤107.69 渭 mol / L, and both of them were higher than control group (P0.01a / L). There was no significant difference in UA levels between subgroups using psychotropic drugs in patients with hypersensitivity disorder (P 0.05). There was no significant correlation between serum UA level and YMRS- Hamd score in patients with bipolar affective disorder (P 0.05). Conclusion the level of serum UA in patients with bipolar disorder may be a biomarker of bipolar disorder.
【作者单位】：北京大学第六医院北京大学精神卫生研究所卫生部精神卫生学重点实验室(北京大学) 国家精神心理疾病临床医学研究中心(北京大学第六医院);北京回龙观医院;
【基金】：首都临床特色应用研究(编号:Z131107002213099)
【分类号】：R749.4

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