Aβ42对果蝇攻击和交配等社交行为的不同调节作用

发布时间：2018-06-11 16:46

本文选题：果蝇 + β淀粉样蛋白　；参考：《福州大学学报(自然科学版)》2017年02期

【摘要】：Aβ42(β-amyloid 42)蛋白聚集的毒性作用可能是阿尔兹海默病(Alzheimer’s disease,AD)的主要病因之一.运用模式生物果蝇研究Aβ42可能对果蝇部分社交行为的影响.首先,在Aβ42果蝇AD模型中观察到Aβ42在果蝇神经中枢蘑菇体区域的聚集和沉积.然后,观察Aβ42果蝇的攻击性,实验发现Aβ42能加速首次攻击时间,并增加攻击频率等.最后,观察Aβ42果蝇的交配行为.实验证明,表达Aβ42可以增强中年果蝇攻击性行为,而对交配取向没有明显作用.实验结果可为后续深入研究Aβ42对攻击性行为影响的神经环路和分子基础提供参考.
[Abstract]:The toxic effect of A 尾 42 (尾 -amyloid 42) protein aggregation may be one of the main causes of Alzheimer's disease (AD). Model organism Drosophila was used to study the effect of A 尾 42 on some social behaviors of Drosophila melanogaster. Firstly, the accumulation and deposition of A 尾 42 in the nervous center of Drosophila melanogaster Agaricus were observed in A 尾 42 AD model. Then, the aggression of A 尾 42 fruit fly was observed. It was found that A 尾 42 could accelerate the first attack time and increase the attack frequency and so on. Finally, the mating behavior of A 尾 42 fruit fly was observed. The results showed that the expression of A 尾 42 could enhance the aggressive behavior of middle aged Drosophila melanogaster, but had no obvious effect on mating orientation. The experimental results may provide a reference for the further study of the neural loop and molecular basis of the effect of A 尾 42 on aggressive behavior.
【作者单位】：上海交通大学Bio-X研究院教育部遗传发育与精神疾病重点实验室;
【基金】：国家自然科学基金资助项目(81371482) 上海教委科研创新重点资助项目(14ZZ028) 上海交通大学医工交叉资助项目(YG2014MS71)
【分类号】：R749.16

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