视神经脊髓炎患者焦虑抑郁与临床特点相关性研究

发布时间：2018-06-13 07:29

本文选题：视神经脊髓炎 + 焦虑　；参考：《四川大学学报(医学版)》2017年06期

【摘要】：目的研究视神经脊髓炎(NMO)患者焦虑、抑郁现状及其与临床特点的相关性。方法对符合标准的NMO患者使用汉密尔顿焦虑量表-14(HARS-14)、汉密尔顿抑郁量表-21(HDRS-21)和扩展残疾状况量表(EDSS)进行评分,并分析焦虑、抑郁障碍与临床特点的关系。结果 65例NMO患者(5例男性,60例女性),平均年龄(39.85±10.36)岁,EDSS评分中位数为2.5分,躯体疼痛平均得分为(37.37±20.44)分,血清NMO-IgG阳性比例76.9%。焦虑评分结果平均值为(11.03±6.95)分,抑郁评分结果平均值为(11.74±7.78)分。65例患者中,有焦虑患者占27.69%(18/65),有抑郁患者占24.62(16/65)。单因素分析显示,EDSS评分与焦虑评分(r=0.285,P=0.004)、抑郁评分(r=0.328,P=0.008)呈低度正相关,躯体疼痛与焦虑评分(r=-0.561,P0.001)、抑郁评分(r=-0.496,P0.001)呈中度负相关,复发次数与焦虑评分(r=0.285,P=0.022)呈低度正相关。年龄、性别、病程、NMO-IgG对患者焦虑、抑郁均无影响。Logistic回归分析显示,躯体疼痛是NMO患者焦虑、抑郁的主要危险因素(比值比分别为1.052、1.046,P0.05)。结论 NMO患者残疾状态与焦虑、抑郁均相关,发作次数与焦虑相关,躯体疼痛是NMO患者焦虑、抑郁的主要危险因素。
[Abstract]:Objective to study the relationship between anxiety, depression and clinical features in patients with NMO-optic neuromyelitis. Methods the patients with NMO were assessed with Hamilton anxiety scale (-14), Hamilton Depression scale (-21 HDRS-21) and extended Disability scale (EDSS), and the relationship between anxiety, depression and clinical characteristics was analyzed. Results among 65 NMO patients, 5 cases were male and 60 cases were female, the median age was 39.85 卤10.36 years old, the median score of EDSS was 2.5, the average score of somatic pain was 37.37 卤20.44, and the positive ratio of NMO-IgG in serum was 76.9. The average score of anxiety score was 11.03 卤6.95, and the average score of depression score was 11.74 卤7.78. Of 65 patients, 27.69 had anxiety and 24.6216 / 65 had depression. Univariate analysis showed that EDSS scores were positively correlated with anxiety scores (r = 0.285) and depression scores (r = 0.328 / P 0.008), somatic pain and anxiety scores (r = -0.561g, P 0.001), depression scores (r = 0.496n, P 0.001), and recurrence times were positively correlated with anxiety scores (r = 0.285 / P = 0.022). Age, sex and course of NMO-IgG had no effect on anxiety and depression. Logistic regression analysis showed that somatic pain was the main risk factor of anxiety and depression in NMO patients. Conclusion the disability state of NMO patients is correlated with anxiety and depression, and the frequency of attack is related to anxiety. Somatic pain is the main risk factor of anxiety and depression in NMO patients.
【作者单位】：四川大学华西医院神经内科;
【基金】：国家自然科学基金(No.81271321) 四川省科技厅项目(No.2013FZ0015)资助
【分类号】：R744.52;R749

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