雌激素与女性认知功能关系的研究进展

发布时间：2018-06-15 03:53

本文选题：认知功能 + 雌激素　；参考：《生殖与避孕》2016年06期

【摘要】：随着女性平均预期寿命的延长及阿尔茨海默病(alzheimer disease,AD)的发病率明显上升,雌激素与女性认知功能的关系研究成为当今学术界研究的热点之一。细胞培养和动物实验数据已经证实,雌激素能通过多种途径保护认知功能相关区域的神经细胞,进而提高认知功能。但是学者们对雌激素水平和女性认知功能的相关性问题,及激素补充治疗(HRT)对围绝经期及绝经后女性认知功能是否有保护作用仍有争议。多数研究表明雌激素水平和女性认知功能是相关的,但是不同的人群,不同时期,不同的认知测试可能会有不同结果。激素补充治疗能否提高女性认知功能取决于研究人群、治疗时机、药物种类及个体化用药等。
[Abstract]:With the prolongation of the average life expectancy of women and the increase of the incidence of Alzheimer's disease (AD), the research on the relationship between estrogen and female cognitive function has become one of the hotspots in academic circles. The results of cell culture and animal experiments have shown that estrogen can protect neural cells in cognitive function related regions through many ways and improve cognitive function. However, there is still controversy about the correlation between estrogen level and women's cognitive function, and whether HRT can protect the cognitive function of women during menopause and postmenopause. Most studies have shown that estrogen levels are associated with women's cognitive function, but different cognitive tests may have different results in different populations, at different times. Whether hormone supplementation therapy can improve women's cognitive function depends on the research population, treatment timing, drug types and individualized medication.
【作者单位】：浙江大学附属妇产科医院;浙江省宁波市鄞州第二医院妇产科;浙江大学附属第二医院神经内科;
【分类号】：R749.16

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