酒依赖患者P300异常和执行功能异常的相关性研究

发布时间：2018-06-17 03:11

本文选题：酒依赖 + 执行功能　；参考：《天津医科大学》2017年硕士论文

【摘要】：目的:探讨男性酒依赖(alcohol dependence,AD)患者的事件相关电位P300异常与执行功能异常的相关性,使用威斯康星卡片分类测验了解AD患者的执行功能。测定AD患者的事件相关电位P300异常与否,为AD执行功能损害提供电生理依据。方法:收集30例男性AD患者为酒依赖组,30名健康男性为对照组,对两组进行威斯康星卡片分类测验(Wisconsin card sorting test,WCST)和事件相关电位P300(event-related potential P300,ERP-P300)测定,酒依赖患者WCST和ERP-P300均在戒断症状消除后评估。结果:1.与健康对照组相比较,研究组患者的Rf、Re及Rpe显著性升高,组间比较具有统计学差异(P0.05),而研究组患者的Cc、Cl显著性降低,组间比较具有统计学差异(P0.05)。2.两组ERP-P300波幅比较情况:研究组患者的N1、N2及P3均显著性低于正常对照组,两组之间比较具有统计学差异(P0.05);两组之间ERP-P300潜伏期比较情况:研究组患者的N2、P3潜伏期显著性长于正常组患者,两组之间比较具有统计学差异(P0.05),而N1与对照组无显著性差别,两组之间比较无统计学差异(P0.05)。3.相关分析显示,研究组患者的Cc与N1波幅呈正相关性(r=-0.879,P=0.0320.05),与N2波幅呈正相关性(r=-0.686,P=0.0270.05),与P3波幅呈正相关性(r=-0.753,P=0.0360.05),与N2潜伏期呈负相关性(r=0.366,P=0.6260.05),与P3潜伏期呈负相关性(r=0.345,P=0.3840.05);研究组患者的Cl与N1波幅呈正相关性(r=-0.776,P=0.0220.05),与N2波幅呈正相关性(r=0.399,P=0.0480.05),与P3波幅呈正相关性(r=0.498,P=0.0310.05),与N2潜伏期呈负相关性(r=0.732,P=0.7280.05),与P3潜伏期呈负相关性(r=0.936,P=0.2560.05);研究组患者的Rf与N1波幅呈负相关性(r=0.680,P=0.3720.05),与N2波幅呈负相关性(r=-0.987,P=0.5680.05),与P3波幅呈负相关性(r=0.259,P=0.4790.05),与N2潜伏期呈正相关性(r=0.456,P=0.0210.05),与P3潜伏期呈正相关性(r=-0.975,P=0.0080.05);研究组患者的Re与N1波幅呈负相关性(r=0.373,P=0.8990.05),与N2波幅呈负相关性(r=-0.674,P=0.1220.05),与P3波幅呈负相关性(r=0.449,P=0.2420.05),与N2潜伏期呈正相关性(r=0.926,P=0.0010.05),与P3潜伏期呈正相关性(r=0.475,P=0.0060.05);研究组患者的Rpe与N1波幅呈负相关性(r=-0.852,P=0.5220.05),与N2波幅呈负相关性(r=-0.673,P=0.4630.05),与P3波幅呈负相关性(r=0.576,P=0.2210.05),与N2潜伏期呈正相关性(r=0.858,P=0.0400.05),与P3潜伏期呈正相关性(r=0.774,P=0.0110.05);研究组患者的N1潜伏期与Cc、Rf、Cl、Re及Rpe之间均无统计学相关性(P0.05)。结论:酒依赖患者存在执行功能障碍,表现为抽象概括、认知转移和反应抑制能力下降及ERP-P300检查谱系中多种结果的异常,主要体现在波幅及潜伏期的改变,ERP-P300的全面检查分析,有助于全面地了解酒依赖患者执行功能障碍的电生理特征。
[Abstract]:Objective: to investigate the correlation between P300 abnormality and executive dysfunction in male alcohol dependence patients, and to investigate the executive function of AD patients by Wisconsin card sorting test. In order to provide electrophysiological evidence for AD executive function damage, the abnormal event related potential (P300) of AD patients was measured. Methods: thirty male patients with AD were collected as alcohol dependent group and 30 healthy men as control group. Wisconsin card sorting test WCSTs and event-related potential P300-related potential P300ERP-P300 were measured in two groups. WCST and ERP-P 300 were evaluated after abstinence symptoms were eliminated. The result is 1: 1. Compared with the healthy control group, the RfN re and RPE in the study group were significantly higher than those in the control group, and there was a statistical difference between the two groups (P 0.05), while the CcnCl level in the study group was significantly lower than that in the control group (P 0.05 路2). Comparison of ERP-P300 amplitudes between the two groups: the N _ 1N _ 2 and P _ 3 of the patients in the study group were significantly lower than those in the normal control group. The latency of ERP-P300 in the study group was significantly longer than that in the normal group, and there was statistical difference between the two groups (P 0.05), but there was no significant difference between the N1 and the control group. There was no statistical difference between the two groups (P 0.05. 3). Correlation analysis shows that There was a positive correlation between the amplitude of cc and N1, a positive correlation between RC and N1 amplitude, a positive correlation with N2 amplitude, a positive correlation with P3 amplitude, a negative correlation with N2 latency, a negative correlation with P3 latency, and a negative correlation between Cl and wave amplitude. There was a positive correlation between RV and N2 amplitude, a positive correlation with N2 amplitude, a positive correlation with P3 amplitude, a negative correlation with N2 latency, a negative correlation with P3 latency, a negative correlation between rf and N1 amplitude, and a negative correlation between rf and N1 amplitude, a negative correlation with N2 latency, and a negative correlation with P3 latency. There was a negative correlation with P3 amplitude, a positive correlation with N2 latency, a positive correlation with P3 latency, a negative correlation between re and N1 amplitude, a negative correlation between re and N1 amplitude, a negative correlation with N2 latency, and a negative correlation with P3 latency. There was a positive correlation between RPE and N1 amplitude, a negative correlation between rpe and N1 amplitude, a negative correlation with N2 amplitude, a negative correlation with P3 amplitude, and a negative correlation between RPE and N1 amplitude, a negative correlation with N2 amplitude, a negative correlation with P3 amplitude, and a negative correlation with P3 amplitude, with a positive correlation between RPE and N1 amplitude, a negative correlation with N2 amplitude, and a negative correlation with P3 amplitude. There was a positive correlation between the N1 latency and the latency of P3, and there was no significant correlation between N1 latency and RFC, ClRe and RPE in the study group (P 0.05), and there was no significant correlation between N1 latency and P3 latency in the study group (P < 0 05), but there was no significant correlation between the N1 latency and the RfN ClRe and RPE in the study group (P < 0 05). Conclusion: there are executive dysfunction in patients with alcohol dependence, such as abstract generalization, decreased cognitive transfer and response inhibition and abnormal results in ERP-P300 pedigree, which are mainly reflected in the changes of amplitude and latency of ERP-P300 and the comprehensive examination and analysis of ERP-P300. It is helpful to understand the electrophysiological characteristics of executive dysfunction in patients with alcohol dependence.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R749.62

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