中国汉族人群5-羟色胺2C受体基因rs518147位点多态性与强迫症的关联性研究

发布时间：2018-06-19 21:32

本文选题：强迫症 + 5-羟色胺2C受体　；参考：《青岛大学》2012年硕士论文

【摘要】：目的：探讨中国汉族群体5-羟色胺2C受体基因(5-HTR2C)启动区相关单核苷酸多态(SNP)位点rs518147多态性的分布状况及其与强迫症易感性之间的关系。方法：采用直接测序法分析中国汉族群体符合中国精神障碍分类与诊断标准第3版或国际疾病分类第10版强迫症诊断标准的患者308例(强迫症组：男123例,女185例)和410名健康对照(对照组：男175例,女235例)5-HTR2Crs518147位点半合子(男性)或基因型(女性)分布频率,并分析半合子(男性)或基因型(女性)分布频率与强迫症发病的遗传易感性的关系。结果：强迫症组中5-HTR2C启动区rs518147位点男性患者携带G半合子与女性患者携带G+(GG与GC)基因型的比率均显著高于对照组(男性：x2=4.973,P=0.026；女性:x2=5.243,P=0.022),G等位基因的频率明显高于对照组(x2=4.611,P=0.032)。结论：中国汉族群体中5-HTR2C启动区rs518147位点多态性可能与强迫症遗传易感性相关。
[Abstract]:Objective: to investigate the distribution of rs518147 polymorphism in the promoter region of serotonin 2C receptor gene (5-HTR2C) and its relationship with susceptibility to obsessive-compulsive disorder (OCD) in Chinese Han population. Methods: a total of 308 patients with obsessive-compulsive disorder (OCD group: 123 males) who met the criteria for the classification and diagnosis of mental disorders in China or the 10th edition of the International Classification of Diseases were analyzed by direct sequencing. The frequencies of heminzygote (male) or genotype (female) of 5-HTR2Crs518147 locus were found in 185 females and 410 healthy controls (control group: 175 males and 235 females). The relationship between the frequency of heminzygote (male) or genotype (female) and the genetic susceptibility of obsessive-compulsive disorder (OCD) was analyzed. Results: in the OCD group, the ratio of G heminzygote and G GG / GC genotype in male patients with 5-HTR2C promoter region was significantly higher than that in the control group (male: x2n 4.973), and in female, the frequency of G allele was significantly higher than that in the control group (male: x25.243), and the frequency of G allele in female was significantly higher than that in the control group (x24.611PU 0.032). Conclusion: the polymorphism of 5-HTR2C rs518147 locus in Chinese Han population may be related to the genetic susceptibility of OCD.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.7

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