广泛性焦虑障碍患者情绪语义无意识加工的事件相关电位研究

发布时间：2018-06-20 16:33

  本文选题：广泛性焦虑障碍 + 事件相关电位　； 参考：《大连医科大学》2013年硕士论文

【摘要】：目的：广泛性焦虑障碍(Generalized anxiety disorder, GAD)又称慢性焦虑，临床以对日常事件或活动过分的、不可控制的担心为特征表现。尽管目前广泛性焦虑障碍的发病机制研究尚未取得一致性的结论，但是广泛性焦虑障碍的信息加工理论以及行为学、影像学结果均提示，情绪信息的自动加工或无意识加工异常可能是广泛性焦虑障碍的重要发病机制之一。 信息无意识加工的特点为无或极少意识参与的信息加工过程，，不占用注意资源，无需意识的发动。阈下启动范式是研究无意识加工的一种广泛的实验范式。由于广泛性焦虑障碍患者担心是一种语义层面的思维活动，即患者反复的不停的思考某些事件会产生的不良后果。因此本实验采用阈下情绪语义启动范式。事件相关电位（event-related potentials, ERP）技术可以将时间精确到毫秒，能动态的反映大脑神经心理活动的时间进程，是研究无意识加工的最佳技术手段。因此，本研究的目的是利用事件相关电位方法探讨广泛性焦虑障碍患者情绪语义无意识加工的特点，并进一步分析不同情绪内容及脑区分布有无特异性。 方法：研究对象包括12例确诊的广泛性障碍患者以及年龄、性别、教育程度相匹配的12名正常对照。所有被试均经过标准化结构访谈程序（SCID）的严格筛查，并完成汉密尔顿焦虑量表(HAMA）及17项汉密尔顿抑郁量表（HAMD-17）评分。本研究采用阈下情绪语义启动范式，情绪启动词语分为负性、正性和中性三种情绪类型，实验任务是对中性图片进行情感等级评分。情绪启动词语和任务图片均选自中国情绪材料数据库。应用64导Neuroscan脑电生理仪来记录事件相关电位。然后，对记录的脑电数据进行离线分析。分别测量额区、顶区、枕区及中央区不同情绪启动词语诱发的P1成分和P3成分的平均波幅及潜伏期。采用重复测量方差分析(Repeated measure ANOVA)对两组ERP成分的平均波幅和潜伏期进行统计分析。 结果： 1.两组被试在不同类别情绪启动词语条件下的反应时(F(1,22)=0.374,p＞0.05)和情感等级评分（F(1,22)=1.419, p＞0.05）未发现显著的组别差异及两者的焦虑。 2.两组被试P1、P3的平均波幅均存在大脑半球主效应（p＜0.05）和电极位置主效应（p＜0.05）。左侧半球平均波幅大于右侧半球，额中央区平均波幅大于顶枕区；两组被试P1、P3的平均波幅未发现组别和情绪类型主效应及两者间的交互效应（p＞0.05）。 3.两组被试P1和P3的潜伏期未发现组别和情绪类别的主效应（p＞0.05），存在半球和电极位置的主效应（p＜0.05）。左半球P1和P3的潜伏期较右半球延迟，额中央区P1和P3的潜伏期较枕顶区延迟。P3的潜伏期存在组别×情绪×半球的交互效应（p＜0.05），即健康对照组左半球负性词语的潜伏期较正性词语延迟，而GAD组左半球负性和正性词语的潜伏期无显著差异。 结论： 1.未发现广泛性焦虑障碍患者存在情绪语义无意识加工的异常。 2.两组被试对情绪语义信息的无意识加工存在加工偏侧化，即左半球额区为汉字情绪语义加工的主要部位。
[Abstract]:Objective: Generalized anxiety disorder (GAD), also known as chronic anxiety, is characterized by excessive and uncontrollable anxiety in daily events or activities. Although the current research on the pathogenesis of generalized anxiety disorder has not been consistent, the information processing theory of generalized anxiety disorder And the behavior, the imaging results suggest that automatic processing of emotional information or unconscious processing abnormalities may be one of the important pathogenesis of generalized anxiety disorder.
Information processing is characterized by no or minimal awareness of the process of information processing, which does not occupy the attention of resources and does not need awareness. Subliminal start - up paradigm is a widespread experimental paradigm for the study of unconscious processing. Thinking about the adverse consequences of certain events. Therefore, this experiment uses the subliminal affective priming paradigm. The event-related potentials (ERP) technology can make time accurate to milliseconds, and can dynamically reflect the time process of brain neuropsychological activity. It is the best technique to study the unconscious processing. The purpose of this study is to explore the characteristics of emotional semantic unconscious processing in patients with generalized anxiety disorder by using the event related potential method, and to further analyze the different emotional content and the distribution of the brain region.
Methods: the subjects included 12 patients with generalized disorder and 12 normal controls of age, sex and education. All subjects were strictly screened by standardized structural interview procedure (SCID), and the Hamilton Anxiety Scale (HAMA) and 17 Hamilton Depression Scale (HAMD-17) scores were completed. The emotional starting words are divided into three types of negative, positive and neutral emotions. The experimental task is to score the emotional grade of neutral pictures. The emotional start words and task pictures are selected from the Chinese emotional material database. The 64 Neuroscan electroencephalogram is used to record the event related potential. Then, the record is recorded. The EEG data were analyzed off-line. The average amplitude and incubation period of P1 and P3 components induced by different emotional priming words in the frontal area, the top area, the pillow area and the central region were measured respectively. The average amplitude and latency of the two groups of ERP components were analyzed by repeated measurement of variance analysis (Repeated measure ANOVA).
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本文编号：2044911