新疆汉维两民族阿尔茨海默氏症患者的牙周健康状况调查

发布时间：2018-06-21 05:21

本文选题：阿尔茨海默氏症 + 认知功能障碍　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:了解新疆汉维两民族阿尔茨海默氏症(Alzheimer’s disease,AD)患者组与认知功能正常组(cognitively normal,CN)的牙周健康状况。方法:选择年龄为50~80岁的被确诊为阿尔茨海默氏症的患者62例(AD组)与认知功能正常者63例(CN组),对所有纳入对象的牙周状况进行检查和评估。通过阿尔茨海默氏症简易智力状况检查表(mini-mental state examination,MMSE)的测评结果来评估所有调查对象的认知损害程度,根据结果进一步将调查对象分为轻、中、重度。检测调查对象的牙龈指数(gingival index,GI)、菌斑指数(plaque index,PI)、探诊深度(probing depth,PD)、牙周附着水平(clinical attachment level,CAL)和出血指数(percentage of bleeding sites,BOP%)。结果:AD组所有的牙周指数均高于CN组,且随着AD的病程进展,其牙周状况愈发恶化,差异具有统计学意义(P0.05)。根据认知损害程度分组,每组之间GI、PI、PD、CAL和BOP%均有显著统计学差异(P0.05)。新疆汉族AD患者牙周状况和新疆维吾尔族AD患者牙周状况的差异无统计学意义(P0.05)。结论:牙周健康状况随着AD的病程进展而逐渐恶化,且与个人的认知功能密切相关。
[Abstract]:Objective: to investigate the periodontal health of patients with Alzheimer's disease (AD) and cognitive normal group (CNC). Methods: 62 patients with Alzheimer's disease aged 50 to 80 years old and 63 patients with normal cognitive function were selected. The periodontal status of all subjects was examined and evaluated. The results of mini-mental state examination were used to evaluate the degree of cognitive impairment in all the subjects, according to the results, the subjects were further divided into three groups: mild, moderate and severe. Gingival index (GI), plaque index (plaque index), probing depth (PD), periodontal attachment level (attachment) and bleeding index (PP) were measured. Results the periodontal index of all patients in the control group was higher than that in the CN group, and the periodontal status deteriorated with the progression of AD, and the difference was statistically significant (P 0.05). According to the degree of cognitive impairment, there were significant statistical differences between the two groups (P 0.05). There was no significant difference in periodontal status between AD patients in Xinjiang and Uygur nationality in Xinjiang (P 0.05). Conclusion: periodontal health status deteriorates with the progression of AD and is closely related to individual cognitive function.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R781.4;R749.16

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