运动通过调控β淀粉样蛋白防治阿尔茨海默病的可能分子机制

发布时间：2018-06-21 12:23

本文选题：阿尔茨海默病 + β淀粉样蛋白　；参考：《天津体育学院学报》2014年01期

【摘要】：阿尔茨海默病(AD)是一种神经退行性疾病,Aβ的过量表达及异常堆积是其发生发展的主要原因之一。本文以β淀粉样蛋白级联假说为线索,阐述了α,β,γ分泌酶对Aβ生成的调节、不同形态Aβ的毒性以及Aβ毒性作用机制。不管是自主运动还是被动运动,中低强度有氧耐力运动均可通过抑制Aβ产生、促进其清除以及抑制其神经毒性作用来预防与缓解AD,但其具体分子生物学机制不甚清楚。因此还探讨了运动如何通过调节α,β,γ分泌酶之间的平衡抑制Aβ的产生;运动如何通过胞外降解、胞内吞噬、转运清除等途径促进Aβ清除;运动如何通过调控机体抗氧化能力、抗炎性反应、细胞凋亡等来抑制Aβ神经毒性。但抗阻运动对缓解AD病症是否仍具有积极意义,目前仍无相关动物实验证实。自噬是一种溶酶体依赖性降解代谢机制,在AD的发病进程中起到重要作用。研究发现,通过激活自噬可增强可溶性或纤维状Aβ的清除,但运动能否通过调控自噬水平促进脑内Aβ清除,也是今后需要解决的重要问题之一。
[Abstract]:Alzheimer's disease (AD) is a neurodegenerative disease, the overexpression and abnormal accumulation of A 尾 is one of the main causes of its occurrence and development. Based on the hypothesis of 尾 -amyloid protein cascade, the regulation of 伪, 尾, 纬 -secretase on A 尾 production, the toxicity of different forms of A 尾 and the mechanism of A 尾 toxicity are discussed in this paper. Whether active exercise or passive exercise, moderate and low intensity aerobic endurance exercise can prevent and alleviate ADD by inhibiting A 尾 production, promoting its clearance and inhibiting its neurotoxicity, but its molecular biological mechanism is not clear. Therefore, it is also discussed how exercise inhibits the production of A 尾 by regulating the balance between 伪, 尾 and 纬 secretory enzymes, how exercise promotes A 尾 clearance through extracellular degradation, intracellular phagocytosis and transport clearance, and how exercise promotes A 尾 clearance by regulating the antioxidant capacity of the body. Anti inflammatory reaction, apoptosis and so on to inhibit A 尾 neurotoxicity. However, whether resistance exercise has positive significance in alleviating AD disease has not been confirmed by animal experiments. Autophagy is a mechanism of lysosomal dependent degradation and metabolism, which plays an important role in the pathogenesis of AD. It has been found that activation of autophagy can enhance the clearance of soluble or fibrous A 尾, but whether exercise can promote the clearance of A 尾 in brain by regulating autophagy level is one of the important problems to be solved in the future.
【作者单位】：华东师范大学体育与健康学院"青少年健康评价与运动干预"教育部重点实验室;
【基金】：国家自然科学基金项目(项目编号:31371204)
【分类号】：R749.16

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