老年人轻度认知功能障碍与血清Klotho蛋白的相关研究

发布时间：2018-06-23 19:05

本文选题：认知功能障碍 + Klotho　；参考：《新疆医科大学》2013年硕士论文

【摘要】：目的：探讨新疆维、汉两民族老年人轻度认知功能障碍(MCI）与Klotho蛋白之间的关系；同时探讨Klotho蛋白在不同民族及性别中有无差异及其与血脂、血糖、血压、年龄等指标的相关性。方法：采用分层、随机、多级整群抽样的方式对新疆地区维、汉两民族≥60岁老年常住居民进行MCI流行病学调查，纳入资料完整的MCI患者161例（MCI组），，其中维吾尔族90人，汉族71人；同时选取民族、性别、年龄及血压相匹配的非MCI者161例（对照组），其中维吾尔族88人，汉族73人。采用酶联免疫吸附法（ELISA）检测血清中Klotho蛋白浓度。结果：（1）MCI组Klotho蛋白浓度（2.48±1.40）ug/L显著低于其对照组的（3.07±1.39）ug/L（P0.05）；（2）维族MCI组的Klotho蛋白浓度（2.21±1.30）ug/L显著低于汉族MCI组的（2.81±1.42）ug/L（P0.05)；维族对照组的Klotho蛋白浓度（2.84±1.36）ug/L显著低于汉族对照组的（3.34±1.37）ug/L（P0.05)。（3）男性MCI组的Klotho蛋白浓度（2.30±1.08）ug/L低于女性MCI组的（2.65±1.60）ug/L，两组间比较差异无统计学意义（P0.05)；男性对照组的Klotho蛋白浓度（2.91±1.18）ug/L低于女性对照组的（3.22±1.55）ug/L，两组间比较差异亦无统计学意义（P0.05)。（4）Klotho蛋白与年龄存在负相关(P0.05)，与胆固醇、低密度脂蛋白、MMSE及MoCa评分存在正相关(P0.05)；但未发现Klotho蛋白与体重、腹围、血糖、血压、高密度脂蛋白等指标存在相关性（P0.05）。结论：（1）Klotho蛋白与MCI的发病相关，推测体内其浓度的降低可能促进了MCI的发生发展。（2）Klotho蛋白在不同民族间存在差异，且维吾尔族低于汉族。但在不同性别间无明显差异。（3）随着人体年龄的增长，体内Klotho蛋白含量有下降趋势。（4）研究发现Klotho蛋白与胆固醇、低密度脂蛋白存在相关性，但未发现与血糖、血压、高密度脂蛋白、腹围及体重有相关性。
[Abstract]:Objective: to investigate the relationship between mild cognitive impairment (MCI) and Klotho protein in the elderly of Uygur and Han nationalities in Xinjiang, and to explore the relationship between Klotho protein and blood lipids, blood glucose, blood pressure, age and so on. Methods: stratified, random and multistage cluster sampling was used to investigate the MCI epidemiology of residents aged more than 60 years old in Xinjiang area. 161 MCI patients (MCI group) with complete data were included, 90 of them were Uygur. There were 71 cases of Han nationality, 161 cases of non-MCI matched by nationality, sex, age and blood pressure (control group), including 88 cases of Uygur nationality and 73 cases of Han nationality. Enzyme linked immunosorbent assay (Elisa) was used to detect the concentration of Klotho protein in serum. Results: (1) the concentration of Klotho protein in MCI group (2.48 卤1.40) ugP / L was significantly lower than that in MCI group (3.07 卤1.39) ugP / L (P0.05); (2), and was significantly lower than that in MCI group (2.81 卤1.42) ug-r-L (P0.05). The concentration of Klotho protein in Uygur group (2.84 卤1.36) ugP / L was significantly lower than that in Han nationality control group (3.34 卤1.37) ugP / L (P0.05). The Klotho protein concentration in male MCI group was (2.30 卤1.08) ugpr / L lower than that in female MCI group (2.65 卤1.60) ugP / L, there was no significant difference between the two groups (P0.05). The concentration of Klotho protein was (2.91 卤1.18) ug-L in male control group and (3.22 卤1.55) ug-L in female control group. There was no significant difference between the two groups (P0.05). Klotho protein was negatively correlated with age (P0.05), and positively correlated with cholesterol, low density lipoprotein (LDL-C) MMSE and MoCa score (P0.05). But there was no correlation between Klotho protein and body weight, abdominal circumference, blood sugar, blood pressure, high density lipoprotein (P0.05). Conclusion: (1) Klotho protein is related to the pathogenesis of MCI, and the decrease of Klotho protein may promote the development of MCI. (2) Klotho protein is different among different nationalities, and it is lower in Uygur than in Han nationality. But there was no significant difference between sexes. (3) with the increase of age, the content of Klotho protein decreased. (4) the study found that Klotho protein was correlated with cholesterol and low density lipoprotein, but not with blood sugar and blood pressure. High density lipoprotein (HDL), abdominal circumference and weight were correlated.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.16

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