氯氮平治疗相关心电图校正QT间期延长及其危险因素

发布时间：2018-06-25 13:43

本文选题：精神分裂症 + 氯氮平　；参考：《中国神经精神疾病杂志》2014年07期

【摘要】：目的调查精神分裂症患者在氯氮平治疗期间心电图校正QT间期(corrected QT interval,QTc)的变化及其相关因素。方法收集使用氯氮平治疗的210例精神分裂症患者,检测心肌酶等生化指标,检查心电图,按Bazett’s公式计算QTc间期,并以桡动脉搏动次数作为心率。结果 QTc间期延长发生率15.24%,女性QTc间期延长发生率高于男性(29.23%vs.8.98%),差异有统计学意义(P0.001)。女性QTc间期比男性长([427.30±24.33)ms vs(.410.39±25.80)ms],差异有统计学意义(P0.001)。QTc间期与年龄(r=0.203,P=0.003)、心率(r=0.326,P0.001)呈正相关,与氯氮平剂量、治疗时间无统计学相关(均P0.05)。多因素线性回归分析示,心率与QTc间期有关联(β=0.719,标准化β=0.691,P=0.027)。结论精神分裂症患者在氯氮平治疗期间QTc间期延长发生率高,心率快可能是其危险因素。
[Abstract]:Objective to investigate the changes and related factors of corrected QT interval (QT intervaline QTc) during clozapine therapy in schizophrenic patients. Methods 210 schizophrenic patients treated with clozapine were collected, myocardial enzyme and other biochemical indexes were detected, electrocardiogram was examined, QTc interval was calculated according to Bazetttsformula, and the heart rate was taken as the beat times of radial artery. Results the rate of prolongation of QTc interval was 15.24 and the rate of QTc interval prolongation in females was higher than that in males (29.23 vs 8.98%). The difference was statistically significant (P0.001). The QTc interval in females was longer than that in males ([427.30 卤24.33) ms vs (.410.39 卤25.80 Ms], the difference was statistically significant (P0.001). QTc interval was positively correlated with age (r = 0.203), heart rate (r = 0.326, P 0.001). There was no significant correlation between QTC interval and clozapine dose, treatment time (P0.05). Multivariate linear regression analysis showed that there was a correlation between heart rate and QTc interval (尾 -0.719, standardized 尾 -0.691P0. 027). Conclusion the incidence of QTc interval prolongation in schizophrenic patients during clozapine therapy is high, and heart rate may be the risk factor.
【作者单位】：北京回龙观医院临床一科;Baylor
【基金】：北京市科技计划项目(编号:D121100005012005)
【分类号】：R749.3

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