注意缺陷多动障碍儿童体内锌含量及T淋巴细胞活性的研究

发布时间：2018-06-26 22:57

本文选题：注意缺陷多动障碍 + 锌　；参考：《中国儿童保健杂志》2014年09期

【摘要】：目的研究注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)患儿体内锌含量及T淋巴细胞亚群活性,以促进ADHD患儿的治疗。方法选择60例ADHD患儿和50例正常对照儿童,采用原子吸收光谱法测定血锌含量,同时采用流式细胞仪检测CD3+、CD4+、CD8+T淋巴细胞亚群活性水平。结果 ADHD组患儿血锌含量(73.24±9.89)μmol/L,明显低于正常对照组[(82.51±7.81)μmol/L,t=5.373,P0.01]。ADHD组患儿CD3+、CD4+、CD4+/CD8+T淋巴细胞活性[(57.9±5.0)%,(26.8±3.9)%,1.059±0.234]较正常对照组[(68.2±4.9)%,(36.5±4.7)%,1.432±0.279]显著降低,差异均有统计学意义(t=10.84,11.85,7.63,P0.01),而两组CD8+无明显差别。相关分析表明血锌与CD4+、CD3+呈正相关(r=0.577,0.411,P0.01)。结论 ADHD患儿血锌含量偏低,存在T淋巴细胞亚群失衡状态,以CD4+T淋巴细胞活性降低为主,补充锌制剂有利于ADHD患儿的治疗。
[Abstract]:Objective to study the content of zinc and the activity of T lymphocyte subsets in children with attention deficit hyperactivity disorder (ADHD) in order to promote the treatment of ADHD. Methods 60 children with ADHD and 50 normal controls were selected to measure the content of zinc in blood by atomic absorption spectrometry and the activity of CD 4 T lymphocyte and CD 8 T lymphocyte subsets by flow cytometry. Results the serum zinc content in ADHD group (73.24 卤9.89) 渭 mol / L was significantly lower than that in normal control group [(82.51 卤7.81) 渭 mol / L ~ (5.373) 渭 mol 路L ~ (-1) P ~ (0.01)]. The activity of CD _ (3) T _ 4 ~ + CD _ 4 ~ + CD _ 8 / CD _ 8 T lymphocyte in ADHD group [(57.9 卤5.0), (26.8 卤3.9) 卤1.059 卤0.234] was significantly lower than that in normal control group [(68.2 卤4.9) 渭 mol / L, (36.5 卤4.7) 渭 mol 路L ~ (-1) 渭 mol 路L ~ (-1) P _ (0.01)], but there was no significant difference in CD8 between the two groups (t _ (10.844) 11.85 ~ (7.63) P ~ (0.01). The correlation analysis showed that there was a positive correlation between blood zinc and CD 4 CD 3 (r 0.577 0. 411 P 0.01). Conclusion the serum zinc content in ADHD children is low and the T-lymphocyte subsets are out of balance. The decrease of CD4 T lymphocyte activity is the main factor. Zinc supplementation is beneficial to the treatment of ADHD children.
【作者单位】：青岛市妇女儿童医院;
【分类号】：R749.94

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