急性脑卒中后认知障碍与血清NSE和CRP的相关性研究

发布时间：2018-07-14 13:11

【摘要】：[目的]认知障碍是急性脑卒中后常见的并发症之一。目前诊断认知障碍，基本上是靠智能量表测定，缺少相应的血清学指标。本研究目的是通过探讨卒中后认知功能障碍的发生和严重程度与外周血清NSE和CRP浓度的相关性，把MMSE（简易智能状态量表）和血清学指标相结合，提高临床对卒中后认知障碍诊断的准确性，并分析其可能的原因，，为疾病早期预测和早期干预提供临床依据。 [方法]依据MMSE量表评定将92例急性脑卒中患者分为卒中后认知障碍组和卒中后无认知障碍组，于发病后第3—5天清晨空腹采取血标本，而后分别采用酶联免疫吸附法和免疫比浊法测定血清NSE和CRP的浓度；其结果与20例正常对照组比较。 [结果]脑卒中患者血清NSE和CRP浓度均高于正常对照组，（P0.05）；卒中后认知障碍组血清NSE和CRP浓度均高于卒中后无认知障碍组，（P0.05），卒中后认知障碍MMSE评分与血清NSE和CRP浓度呈负相关。 [结论]血清NSE和CRP浓度与卒中后认知障碍关系密切，可反映脑卒中患者的认知障碍程度，因此血清NSE和CRP可作为卒中后认知障碍的生物学检测指标，检测其浓度和量表评定相结合可以做为卒中后认知障碍的辅助诊断指标，为临床上对卒中后认知障碍的早发现、早治疗提供依据。另外，认知障碍的发生与脑卒中的部位及卒中面积都有一定的关系，但前者的影响可能更多，因本研究病例数量较少，因此还有待进一步研究。
[Abstract]:Objective: cognitive impairment is one of the common complications after acute stroke. At present, the diagnosis of cognitive impairment is based on intelligence scale, lack of corresponding serological indicators. The purpose of this study was to investigate the correlation between the occurrence and severity of cognitive dysfunction and the levels of NSE and CRP in peripheral blood of patients with stroke, and to combine MMSE with serological indexes. To improve the accuracy of clinical diagnosis of post-stroke cognitive disorder and analyze its possible causes, to provide clinical basis for early disease prediction and early intervention. [methods] according to the MMSE scale, 92 patients with acute stroke were divided into two groups: the post-stroke cognitive impairment group and the post-stroke no cognitive impairment group. Blood samples were taken on an empty stomach on the 3-5 days after the onset of stroke. The serum levels of NSE and CRP were determined by enzyme-linked immunosorbent assay (Elisa) and immunoturbidimetry respectively, and the results were compared with those of 20 normal controls. [results] the levels of serum NSE and CRP in stroke patients were higher than those in normal controls (P0.05), and the levels of NSE and CRP in post-stroke cognitive impairment group were higher than those in no cognitive impairment group after stroke (P0.05), the MMSE scores of post-stroke cognitive impairment were negatively correlated with serum NSE and CRP levels. [conclusion] Serum NSE and CRP levels are closely related to post-stroke cognitive impairment, which can reflect the degree of cognitive impairment in stroke patients. Therefore, serum NSE and CRP can be used as biological markers of post-stroke cognitive impairment. It can be used as an auxiliary diagnostic index of post-stroke cognitive impairment, which can provide evidence for early detection and early treatment of post-stroke cognitive impairment. In addition, the occurrence of cognitive impairment has a certain relationship with the location and area of stroke, but the former may have more influence, because the number of cases in this study is relatively small, so it needs further study.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.1

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