血液中花生四烯酸乙醇胺含量与精神分裂症发病机制的研究
发布时间：2018-07-15 15:10
【摘要】：目的分析精神分裂症患者血液中花生四烯酸乙醇胺(AEA)含量的变化,探讨与精神分裂症病理之间的联系。方法采集56例精神分裂症患者静脉血液样本,应用高效液相色谱法(HPLC)柱前衍生化测定精神分裂症患者血液样品中AEA含量变化;并与40例健康者血液中AEA含量进行比较。结果精神分裂症患者血液中AEA含量明显高于对照组[(23.87±1.32)ng/mL vs(11.26±0.81 ng/mL)],两组样本间差异有统计学意义(P0.05)。结论精神分裂症患者症状活跃期间血液中AEA含量增高,可能与精神分裂症的发病机制有关,该结果为精神分裂疾病药物研发提供新思路。
[Abstract]:Objective to analyze the changes of blood levels of ethanolamine arachidonate (AEA) in patients with schizophrenia and to explore the relationship between AEA and pathology of schizophrenia. Methods the changes of AEA in 56 patients with schizophrenia were measured by HPLC precolumn derivatization and compared with that of 40 healthy controls. Results the AEA content in the blood of schizophrenic patients was significantly higher than that in the control group [(23.87 卤1.32) ng / mL vs (11.26 卤0.81 ng / mL)], and the difference between the two groups was statistically significant (P0.05). Conclusion the increase of AEA in the blood during the active period of schizophrenia may be related to the pathogenesis of schizophrenia, which provides a new idea for the development of drugs for schizophrenia.
【作者单位】： 重庆三峡医药高等专科学校;重庆三峡中心医院;重庆医科大学;
【基金】：重庆市基础与前沿研究计划项目(No:cstc2014ja10049) 重庆市卫生局医学科研项目(No:2012-1-096) 重庆市高等教育教学改革研究重点项目(No:132128,133309) 重庆万州区科技计划项目(No:201203055)
【分类号】：R749.3
本文编号：2124492
[Abstract]:Objective to analyze the changes of blood levels of ethanolamine arachidonate (AEA) in patients with schizophrenia and to explore the relationship between AEA and pathology of schizophrenia. Methods the changes of AEA in 56 patients with schizophrenia were measured by HPLC precolumn derivatization and compared with that of 40 healthy controls. Results the AEA content in the blood of schizophrenic patients was significantly higher than that in the control group [(23.87 卤1.32) ng / mL vs (11.26 卤0.81 ng / mL)], and the difference between the two groups was statistically significant (P0.05). Conclusion the increase of AEA in the blood during the active period of schizophrenia may be related to the pathogenesis of schizophrenia, which provides a new idea for the development of drugs for schizophrenia.
【作者单位】： 重庆三峡医药高等专科学校;重庆三峡中心医院;重庆医科大学;
【基金】：重庆市基础与前沿研究计划项目(No:cstc2014ja10049) 重庆市卫生局医学科研项目(No:2012-1-096) 重庆市高等教育教学改革研究重点项目(No:132128,133309) 重庆万州区科技计划项目(No:201203055)
【分类号】：R749.3
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