磷酸二酯酶亚型与阿尔采末病认知障碍的关系及相关治疗策略
发布时间：2018-07-21 11:02
【摘要】：阿尔采末病(AD)是一种中枢神经系统退行性疾病,为最常见的痴呆类型。磷酸二酯酶包括一组水解细胞内第二信使环磷酸腺苷和(或)环磷酸鸟苷的酶,已证实磷酸二酯酶抑制剂(PDE-Is)对AD动物模型有积极的作用,如PDE4-I咯利普兰、PDE5-I西地那非。本文对PDE-Is改善AD认知功能及其作用机制作一综述,旨在为后续研发新的PDE-Is用于AD的治疗提供思路。
[Abstract]:Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system and is the most common type of dementia. Phosphodiesterase includes a group of enzymes that hydrolyze the second messenger adenosine monophosphate and / or cyclic guanosine monophosphate. It has been shown that phosphodiesterase inhibitors (PDE-Is) play a positive role in AD animal models, such as PDE4-I and PDE 5-I sildenafil. This article reviews the improvement of cognitive function and its mechanism in AD by PDE-Is in order to provide ideas for the development of new PDE-Is for AD treatment.
【作者单位】： 遵义医学院药理学教研室暨基础药理省部共建教育部重点实验室;
【基金】：教育部“长江学者和创新团队发展计划”创新团队(IRT1197) 贵州省科技厅优秀青年科技人才资金(黔科合人字[2013]26)
【分类号】：R749.16
[Abstract]:Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system and is the most common type of dementia. Phosphodiesterase includes a group of enzymes that hydrolyze the second messenger adenosine monophosphate and / or cyclic guanosine monophosphate. It has been shown that phosphodiesterase inhibitors (PDE-Is) play a positive role in AD animal models, such as PDE4-I and PDE 5-I sildenafil. This article reviews the improvement of cognitive function and its mechanism in AD by PDE-Is in order to provide ideas for the development of new PDE-Is for AD treatment.
【作者单位】： 遵义医学院药理学教研室暨基础药理省部共建教育部重点实验室;
【基金】：教育部“长江学者和创新团队发展计划”创新团队(IRT1197) 贵州省科技厅优秀青年科技人才资金(黔科合人字[2013]26)
【分类号】：R749.16
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