静息态功能磁共振下抑郁症默认网络功能连接的研究

发布时间：2018-07-22 11:59

【摘要】：目的分析静息态下抑郁症患者默认网络(default mode netwoks,DMN)功能连接的变化,探讨默认网络在抑郁症发病机制中的作用及其与抑郁症临床特征的相关性。方法收集16例抑郁症患者和15名正常对照者完成静息态功能磁共振扫描,比较两组间默认网络内脑区的功能连接强度,采用汉密尔顿抑郁量表(Hamiliton depression rating scale,HAMD)评估患者抑郁症状,分析患者默认网络功能连接与其临床特征的相关性。结果相较于对照组,患者组后扣带回与右侧颞叶、右前额叶、右侧顶叶,左前额叶内侧皮质与右侧扣带回、右侧前额叶,右海马与右前额叶、右侧顶叶,以及左海马与左前额叶、左侧枕叶功能连接增强(P0.01);前额叶内侧皮质与左前额叶,右海马与右侧颞叶、左侧边缘叶,左海马与右前额叶(额上回)、右旁中央小叶的功能连接强度下降(P0.01)。患者组左侧前额叶内侧皮质—左侧海马间的功能连接强度与HAMD总分(r=-0.569,P=0.021)及迟缓因子分(r=-0.498,P=0.050)呈负相关;左侧前额叶内侧皮质—右侧海马功能连接强度与HAMD总分呈负相关(r=-0.508,P=0.045);两侧海马间的功能连接强度与HAMD认知障碍因子分呈负相关(r=-0.509,P=0.044)。结论静息状态下,未用药抑郁症患者默认网络功能连接存在异常改变,且部分功能连接强度变化与其临床症状存在相关性。
[Abstract]:Objective to analyze the changes of default network (default mode netwoksl) functional connections in depression patients under resting condition, and to explore the role of default network in the pathogenesis of depression and its correlation with the clinical features of depression. Methods 16 patients with depression and 15 normal controls were examined with resting functional magnetic resonance imaging (fMRI). The intensity of functional connections in the default network between the two groups was compared, and the depression symptoms were evaluated by Hamilton depression rating scale (Hamd). To analyze the correlation between patients' default network function connection and their clinical features. Results the posterior cingulate gyrus and right temporal lobe, right prefrontal lobe, right parietal lobe, medial cortex of left prefrontal lobe and right cingulate gyrus, right prefrontal lobe, right hippocampus and right prefrontal lobe, right parietal lobe, right hippocampal cortex and right prefrontal lobe, right parietal lobe, right prefrontal lobe The functional connections of left hippocampus and left prefrontal lobe, left occipital lobe, medial prefrontal cortex and left prefrontal lobe, right hippocampus and right temporal lobe, left marginal lobe, The intensity of functional connections between left hippocampus and right prefrontal lobe (superior frontal gyrus) and right paracentral lobule decreased (P0.01). The intensity of functional connection between left medial prefrontal cortex and left hippocampus was negatively correlated with the total score of Hamd (r = 0.569) and the score of retardation factor (r = 0.498). The intensity of the left medial prefrontal cortex-right hippocampal junction was negatively correlated with the total score of Hamd (r = 0.508), and the intensity of the bilateral hippocampus was negatively correlated with the scores of the cognitive impairment factor of Hamd (r ~ (-0.509) P ~ (0.044). Conclusion there are abnormal changes in the default network functional connections in patients with depression without medication under resting condition, and the changes in the intensity of some functional connections are correlated with their clinical symptoms.
【作者单位】：上海交通大学医学院附属精神卫生中心心境障碍科;华东师范大学物理系;同济大学附属同济医院放射科;
【基金】：上海市科委医学(西医)引导类项目(编号:134119b0400) 上海市科学技术委员会“登山计划”(编号:06JC14061) 国家高技术研究发展计划(863计划)项目(编号:2006AA02Z430) 国家自然科学基金(编号:91232719) “十二五”国家科技支撑项目(编号:2012BAIO1B04) 国家重点临床专科—上海市精神卫生中心(编号:卫生部医政司2011-873)
【分类号】：R749.4

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