精神分裂症血清补体C3、C4、超敏C-反应蛋白及尿酸水平变化

发布时间：2018-07-22 20:37

【摘要】：目的探讨精神分裂症(schizophrenia,SZ)患者血清补体C3(complement component 3,C3)、C4(complement component 4,C4)、超敏C-反应蛋白(high sensitivity C reactive protein,hs-CRP)和尿酸(uric acid,UA)的水平变化及其临床意义。方法选择144例SZ患者为SZ组,并根据4周内有无服用抗精神病药物分为治疗组(77例)和停药组(67例),另选择同期来湘雅二医院的健康体检者147例为健康对照组。采用免疫散射比浊法、胶乳增强免疫比浊法、尿酸氧化酶法分别测定各组血清补体C3、C4、hs-CRP和UA浓度,并比较分析。结果 SZ组患者血清补体C3、C4水平低于对照组[(0.99±0.17)g/L vs.(1.03±0.17)g/L、(0.21±0.05)g/L vs.(0.23±0.05)g/L],UA水平高于对照组[(351.61±95.90)μmol/L vs.(300.28±39.57)μmol/L],差异有统计学意义(分别P0.05,P0.05,P0.001)。治疗组患者血清补体C3、C4、hs-CRP和UA水平较停药组均升高[(1.04±0.19)g/L vs.(0.95±0.15)g/L、(0.22±0.06)g/L vs.(0.20±0.05)g/L、1.08(0.33,5.04)mg/L vs.0.47(0.28,1.29)mg/L、(374.54±108.33)μmol/L vs.(331.61±79.03)μmol/L],差异均有统计学意义(P0.01)。治疗组患者血清hs-CRP和UA浓度较对照组均升高[1.08(0.33,5.04)mg/L vs.0.61(0.33,1.26)mg/L、(374.54±108.33)μmol/L vs.(300.28±39.57)μmol/L],差异有统计学意义(P0.001)。结论 SZ患者血清C3、C4、hs-CRP和UA的水平变化对SZ临床诊断和抗精神病药物疗效评估有一定指导意义。
[Abstract]:Objective To investigate the changes of serum complement C3 ( C3 ) , C4 ( complement component 4 , C4 ) , hypersensitive C - reactive protein ( hs - CRP ) and uric acid ( UA ) in patients with schizophrenia ( schizophrenia , SZ ) . The levels of serum hs - CRP and UA in the treatment group were significantly higher than those in the control group ( P 0.01 ) . The levels of serum hs - CRP and UA in the treatment group were significantly higher than those in the control group ( P 0.01 ) . The levels of serum levels of serum hs - CRP and UA in the treatment group were significantly higher than those in the control group ( P < 0.01 ) .
【作者单位】：湖南中医药大学医学院;中南大学湘雅二医院检验科;中南大学湘雅二医院(精神卫生研究所);
【基金】：国家自然科学基金资助项目(编号:81503276,81771448) 湖南省教育厅项目(编号:15C1044) 湖南省大学生创新性课题(编号:2017-310) 湖南中医药大学大学生创新性课题(编号:2016-21)
【分类号】：R749.3

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