~1H-MRS检测儿童及青少年创伤后应激障碍大脑前扣带回代谢物改变
发布时间：2018-07-23 08:17
【摘要】：目的探讨儿童及青少年创伤后应激障碍(PTSD)患者1 H-MRS中大脑前扣带回区代谢物水平的变化。方法纳入汶川地震幸存者57人,包括10例PTSD患者、23名PTSD康复者和24名健康者。对所有研究对象行1 H-MRS检查,检测大脑前扣带回区N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)、肌醇(MI)和谷氨酸和谷氨酰胺复合物(Glx)水平,计算并比较NAA/Cr、Glx/Cr、Cho/Cr、MI/Cr的差异。结果 Glx/Cr:PTSD患者(1.16±0.15)、PTSD患者+PTSD康复者(1.31±0.07)均明显低于健康者(1.59±0.10),PTSD患者明显低于PTSD康复者+健康者(1.48±0.07),差异均有统计学意义(P均0.05),PTSD康复者(1.37±0.08)与健康者和PTSD患者间差异均无统计学意义(P均0.05)。NAA/Cr、Cho/Cr和MI/Cr差异均无统计学意义(P均0.05)。结论 1 H-MRS中儿童及青少年PTSD患者大脑前扣带回区Glx明显下降,其改变可能在PTSD病理生理机制中发挥重要作用。
[Abstract]:Objective to investigate the changes of 1 H-MRS metabolites in anterior cingulate gyrus in children and adolescents with post-traumatic stress disorder (PTSD). Methods 57 survivors of Wenchuan earthquake were included, including 10 PTSD patients and 23 recovered PTSD patients and 24 healthy people. All subjects were examined with 1H-MRS and the levels of NAA, Cr, Cho, MI and Glx in the anterior cingulate gyrus were measured, and the difference of NAA / Cr / GlX / CrCho-CrMIP / Cr was calculated and compared with that of NAA- / Cr-GlX / CrCho-CrMI-r / Cr in the anterior cingulate gyrus (ACA / Cr), and the levels of creatine (Cr), choline (Cho), inositol (MI) and glutamic acid / glutamine complex (Glx) were measured. Results (1.16 卤0.15) PTSD patients (1.31 卤0.07) were significantly lower than those in healthy people (1.59 卤0.10). The difference was statistically significant (P 0.05) between PTSD rehabilitation patients (1.37 卤0.08), healthy persons and PTSD patients. There was no significant difference between NAA / Cr / Cr and MIP / Cr (P 0.05). Conclusion 1Glx in the anterior cingulate gyrus of children and adolescents with PTSD in H-MRS is significantly decreased, which may play an important role in the pathophysiological mechanism of PTSD.
【作者单位】： 武汉大学物理科学与技术学院医学物理实验室;
【基金】：国家自然科学基金(10875092) 湖北省自然科学基金(2012FKB04449)
【分类号】：R445.2;R749.99
，
本文编号：2138774
[Abstract]:Objective to investigate the changes of 1 H-MRS metabolites in anterior cingulate gyrus in children and adolescents with post-traumatic stress disorder (PTSD). Methods 57 survivors of Wenchuan earthquake were included, including 10 PTSD patients and 23 recovered PTSD patients and 24 healthy people. All subjects were examined with 1H-MRS and the levels of NAA, Cr, Cho, MI and Glx in the anterior cingulate gyrus were measured, and the difference of NAA / Cr / GlX / CrCho-CrMIP / Cr was calculated and compared with that of NAA- / Cr-GlX / CrCho-CrMI-r / Cr in the anterior cingulate gyrus (ACA / Cr), and the levels of creatine (Cr), choline (Cho), inositol (MI) and glutamic acid / glutamine complex (Glx) were measured. Results (1.16 卤0.15) PTSD patients (1.31 卤0.07) were significantly lower than those in healthy people (1.59 卤0.10). The difference was statistically significant (P 0.05) between PTSD rehabilitation patients (1.37 卤0.08), healthy persons and PTSD patients. There was no significant difference between NAA / Cr / Cr and MIP / Cr (P 0.05). Conclusion 1Glx in the anterior cingulate gyrus of children and adolescents with PTSD in H-MRS is significantly decreased, which may play an important role in the pathophysiological mechanism of PTSD.
【作者单位】： 武汉大学物理科学与技术学院医学物理实验室;
【基金】：国家自然科学基金(10875092) 湖北省自然科学基金(2012FKB04449)
【分类号】：R445.2;R749.99
，
本文编号：2138774
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