伴强迫症状的首发儿童精神分裂症患者的认知功能和病前行为特征调查

发布时间：2018-08-08 13:34

【摘要】：目的调查伴与不伴强迫症状的儿童精神分裂症患者之间病后认知功能和病前行为特征的差异。方法选取儿童精神分裂症患者149例为患者组,72名正常儿童为对照组。根据学龄儿童情感障碍和精神分裂症问卷(the schedule for affective disorders and schizophrenia for school-age children-present and lifetime version,K-SADS-PL)将患者组患儿分为伴强迫症状组(70例)与不伴强迫症状组(79例)。采用Achenbach儿童行为量表(child behaviour check-list,CBCL)回顾性调查所有入组儿童6~10岁的行为特征;采用中国韦氏儿童智力测验、Stroop色—词测验、连线测验、视觉空间记忆、迷宫测验对所有入组儿童进行认知功能的评估。结果CBCL量表测评显示,两患者组既往行为问题总分均高于对照组(P0.01),社会能力总分均低于对照组(P0.05);伴强迫组学校情况(P0.01)、分裂强迫(P0.01)以及体诉因子分(P0.01)均高于不伴强迫组。认知功能测评显示,两患者组所有因子评分均低于对照组(P0.05),伴强迫组常识(P0.01)、木块(P0.01)、Stroop色—词关联测验(P0.01)以及视觉空间记忆评分(P0.01)低于不伴强迫组。病前行为特征与病后认知功能相关分析显示,伴强迫组社会能力总分与类同评分呈正相关(r=0.31,P0.01);不伴强迫组行为问题总分与木块评分(r=-0.31,P0.01)、拼凑评分(r=-0.32,P0.01)呈负相关。结论伴强迫症状的首发儿童精神分裂症患者病前存在更多的行为问题,病后认知功能更差。伴与不伴强迫症状的首发儿童精神分裂症患者病后认知功能均与病前行为问题、社会能力存在相关关系。
[Abstract]:Objective to investigate the difference of postmortem cognitive function and premortem behavior between children with and without obsessive-compulsive symptoms. Methods 149 children with schizophrenia were selected as control group and 72 normal children as control group. According to the (the schedule for affective disorders and schizophrenia for school-age children-present and lifetime version K-SADS-PL of affective disorder and schizophrenia of school-age children, the patients were divided into two groups: the group with obsessive-compulsive symptoms (n = 70) and the group without obsessive-compulsive symptoms (n = 79). The behavioral characteristics of all the children aged 6 to 10 years were investigated retrospectively by using the Achenbach Children's behavior scale (child behaviour check-listCBCL), and the Chinese Wechsler Intelligence Test (Wechsler) was used to test the Stroop color-word test, line test and visual spatial memory. The labyrinth test assessed the cognitive function of all children in the group. Results the CBCL scale showed that the total scores of past behavior problems in the two groups were higher than those in the control group (P0.01), the total scores of social ability were lower than those in the control group (P0.05), the school condition (P0.01), split compulsion (P0.01) and body complaint factor (P0.01) in the group with obsessive compulsion were higher than those in the group without obsessive compulsion (P0.01). Cognitive function test showed that the scores of all factors in the two groups were lower than those in the control group (P0.05). The scores of common sense (P0.01), Stroop color-word association test (P0.01) and visual spatial memory (P0.01) in the two groups were lower than those in the non-compulsive group (P0.01). The correlation analysis between pre-illness behavior and cognitive function showed that the total score of social ability was positively correlated with the same score (r = 0.31, P 0.01), the total score of behavior problems without obsessive-compulsive group was negatively correlated with the score of wood block (r = -0.31, P 0.01), and the score of patching together (r = -0.32, P 0.01) was negatively correlated with the score of wood block. Conclusion there are more behavioral problems and worse cognitive function in children with first episode schizophrenia with obsessive compulsive symptoms. The cognitive function of children with and without obsessive-compulsive symptoms was correlated with pre-illness behavior and social ability.
【作者单位】：新乡医学院第二附属医院儿童少年精神科;
【基金】：河南省重点科技攻关项目(编号:132102310446)
【分类号】：R749.3

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