首发未服药女性抑郁障碍患者认知事件相关电位P300与脑灰质体积的相关性研究
发布时间：2018-08-08 14:57
【摘要】：目的： 采用基于体素的形态学分析(Voxel-based morphometry, VBM)方法探讨首次发病未服药女性抑郁障碍患者脑灰质体积变化特点,并探讨认知事件相关电位P300潜伏期和波幅与脑灰质体积以及临床特点之间的关系,以发现影响首次发病未服药女性抑郁障碍患者认知功能的神经病理基础。 方法： 对昆明医科大学第一附属医院25例符合DSM-Ⅳ诊断标准的首次发病未服药女性抑郁障碍患者(患者组)和28例年龄、文化程度匹配的健康对照(对照组)分别进行头部3D结构磁共振扫描,并对患者组进行认知事件相关电位P300检查。所得到的结构磁共振数据采用基于Matlab2009a软件平台上的VBM5软件进行自动化分割处理,分别分割出患者组和对照组的脑灰质体积；采用两样本t检验来观察MDD患者相对于健康对照脑灰质体积异常的区域：将认知事件相关电位P300的波幅和潜伏期与脑灰质体积进行相关分析,寻找与认知事件相关电位P300相关的特异脑区；采用Spearman相关分析探讨认知事件相关电位P300与临床特点的相关性。 结果： 1.与健康常模比较,首次发病未服药女性抑郁障碍患者P2潜伏期延长,P3波幅增高(p0.05),其他成分差异无统计学意义(p0.05),P300各成分与HAMD总分和各因子分相关性无统计学意义(p0.05)。 2.与对照组相比,首次发病未服药女性抑郁障碍患者右侧额下回岛盖部,右侧中央前回灰质体积减小。 3.患者组认知事件相关电位P300中的不同成分分别与不同脑区灰质体积相关,其中P3、N2潜伏期均与双侧壳核正相关；P3潜伏期还与双侧颞中回、左侧额中回、左侧梭状回正相关,而P3波幅则仅与左侧角回、右侧额上回负相关；N2潜伏期与左侧后扣带回、右侧梭状回、枕叶、左侧小脑正相关。N1潜伏期主要与左侧小脑正相关,与左侧颞下回、海马旁回和右侧颞上回、颞中回负相关；P2潜伏期主要与双侧颞上回、左侧楔前叶、舌回、后扣带回、中央旁小叶和右侧颞中回正相关,与左侧前扣带回负相关。 4.患者的抑郁量表总分及因子分分别与不同脑区灰质体积存在相关。HAMD总评分主要与右侧枕上回负相关；焦虑/躯体化因子分与左侧梭状回、右侧尾状核、小脑蚓和两侧小脑负相关；迟滞因子分与左侧额叶、中央前回、前扣带回、颞上回、颞中回和双侧眶额部皮质、双侧额下回三角部正相关,与双侧枕叶负相关；认知障碍因子分与左侧额下回岛盖部、中央后回正相关,与右侧枕上回负相关；睡眠障碍因子分与左侧颞极颞上回、右侧中央后回正相关；而体重因子分与双侧海马旁回负相关。 结论： 1.与健康对照比较,首次发病未服药女性抑郁障碍患者存在脑灰质体积减小,提示未经治疗女性抑郁患者存在特征性脑灰质体积异常。 2.患者的抑郁量表总分及因子分分别与不同脑区体积存在相关,提示这些不同的抑郁症状可能有不同的脑结构基础。 3.患者认知事件相关电位P300存在异常,但是与抑郁严重程度无关；认知事件相关电位P300的各成分分别与多个灰质体积具有相关性,提示不同脑区灰质体积分别对认知事件相关电位P300不同成分具有不同影响,即女性抑郁患者的认知功能障碍受多个脑区或神经环路的共同影响,尤以颞叶、基底神经节的影响较为明显。支持女性抑郁障碍患者的认知功能障碍相对独立,且与抑郁症状存在不同的脑结构基础。
[Abstract]:Objective:
Voxel-based morphometry (VBM) was used to investigate the changes in the volume of gray matter volume in the first onset of untreated women with depressive disorder, and the relationship between the latency and amplitude of the cognitive event related potential and the amplitude of the cerebral gray matter, the volume of gray matter and the clinical characteristics of the patients were investigated in order to find the influence of the first onset of untreated women. Neuropathological basis of cognitive function in patients with depressive disorder.
Method:
In the First Affiliated Hospital of Kunming Medical University, 25 cases of female depressive disorder (patient group) and 28 age and healthy controls (control group) with DSM- IV diagnostic criteria were performed on the head 3D structure magnetic resonance imaging (MRI), and the cognitive event related potential P300 examination of the patients was performed. The structural magnetic resonance data were automatically divided by VBM5 software based on the Matlab2009a software platform to separate the volume of cerebral gray matter in the patient group and the control group, and the two sample t test was used to observe the area of the MDD patients relative to the healthy control brain gray matter volume abnormality: the amplitude and potential of the cognitive event related potential P300. The correlation analysis between the volt period and the volume of cerebral gray matter was carried out to find the specific brain regions associated with the cognitive event related potential P300, and the correlation between the P300 and the clinical characteristics was investigated by Spearman correlation analysis.
Result:
1. compared with the normal health model, the P2 latency of the first onset untreated women with depressive disorder was prolonged, the amplitude of P3 increased (P0.05), and the differences in other components were not statistically significant (P0.05). There was no statistically significant correlation between the components of P300 and the total score of HAMD and the factors of each factor (P0.05).
2. Compared with the control group, the gray matter volume of right inferior frontal gyrus and right anterior central gyrus decreased in the first-onset female depressive disorder.
The different components of the cognitive event related potential P300 in the 3. patients were related to the volume of gray matter in different brain regions, and the latency of P3 and N2 was positively correlated with the bilateral putamen, and the latency of P3 was correlated with bilateral temporal gyrus, left middle frontal gyrus and left fusiform gyrus, while the P3 amplitude was negatively correlated with the left lateral gyrus and the right frontal gyrus, and N2 latency and left The posterior cingulate gyrus, right fusiform gyrus, occipital lobe and left cerebellum related.N1 latency are mainly related to the left cerebellum, which are negatively related to the left temporal gyrus, parahippocampal gyrus, right temporal gyrus and temporal gyrus, and the P2 latency is mainly related to the bilateral superior temporal gyrus, the left anterior lobe, the lingual gyrus, the posterior cingulate gyrus, the parapara lobule and the right temporal gyrus, and the left side. The anterior cingulate gyrus was negatively correlated.
4. the total score and factor score of 4. patients were negatively correlated with the right occipital gyrus on the right, and the scores of anxiety / somatization factor were negatively correlated with the left fusiform gyrus, right caudate nucleus, cerebellar vermis and bilateral cerebellum, and the lag factor was associated with the left frontal lobe, the anterior central gyrus, the anterior cingulate gyrus, and the upper temporal gyrus. The middle temporal gyrus and bilateral orbital frontal cortex, bilateral inferior frontal gyrus and bilateral occipital lobe are negatively correlated with bilateral occipital lobe; cognitive impairment factor is related to the left inferior frontal gyrus, the posterior central gyrus and the right occipital gyrus, and the sleep barrier factor is related to the left temporal superior temporal gyrus and right posterior central gyrus; and the body weight factor and bilateral side are both bilateral and bilateral. The parahippocampal gyrus was negatively correlated.
Conclusion:
1. compared with the health control, the volume of brain gray matter decreased in the first untreated women with depressive disorder, suggesting that the untreated women with depression have the characteristic gray matter volume abnormality.
2. The total score and factor score of depression scale were correlated with different brain area volume, suggesting that these different depressive symptoms may have different brain structure basis.
3. patients with cognitive event related potential P300 were abnormal, but had nothing to do with the severity of depression; the components of the cognitive event related potential P300 were related to the volume of multiple gray matter respectively, suggesting that the volume of gray matter in different brain regions had different effects on the different components of the cognitive event related potential P300, namely, the cognitive work of women with depression. The disturbance of energy is influenced by multiple brain regions or nerve loops, especially in the temporal lobe and the basal ganglia. The cognitive dysfunction of the patients with depressive disorder is relatively independent, and there are different brain structural bases from the depressive symptoms.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.4
本文编号：2172142
[Abstract]:Objective:
Voxel-based morphometry (VBM) was used to investigate the changes in the volume of gray matter volume in the first onset of untreated women with depressive disorder, and the relationship between the latency and amplitude of the cognitive event related potential and the amplitude of the cerebral gray matter, the volume of gray matter and the clinical characteristics of the patients were investigated in order to find the influence of the first onset of untreated women. Neuropathological basis of cognitive function in patients with depressive disorder.
Method:
In the First Affiliated Hospital of Kunming Medical University, 25 cases of female depressive disorder (patient group) and 28 age and healthy controls (control group) with DSM- IV diagnostic criteria were performed on the head 3D structure magnetic resonance imaging (MRI), and the cognitive event related potential P300 examination of the patients was performed. The structural magnetic resonance data were automatically divided by VBM5 software based on the Matlab2009a software platform to separate the volume of cerebral gray matter in the patient group and the control group, and the two sample t test was used to observe the area of the MDD patients relative to the healthy control brain gray matter volume abnormality: the amplitude and potential of the cognitive event related potential P300. The correlation analysis between the volt period and the volume of cerebral gray matter was carried out to find the specific brain regions associated with the cognitive event related potential P300, and the correlation between the P300 and the clinical characteristics was investigated by Spearman correlation analysis.
Result:
1. compared with the normal health model, the P2 latency of the first onset untreated women with depressive disorder was prolonged, the amplitude of P3 increased (P0.05), and the differences in other components were not statistically significant (P0.05). There was no statistically significant correlation between the components of P300 and the total score of HAMD and the factors of each factor (P0.05).
2. Compared with the control group, the gray matter volume of right inferior frontal gyrus and right anterior central gyrus decreased in the first-onset female depressive disorder.
The different components of the cognitive event related potential P300 in the 3. patients were related to the volume of gray matter in different brain regions, and the latency of P3 and N2 was positively correlated with the bilateral putamen, and the latency of P3 was correlated with bilateral temporal gyrus, left middle frontal gyrus and left fusiform gyrus, while the P3 amplitude was negatively correlated with the left lateral gyrus and the right frontal gyrus, and N2 latency and left The posterior cingulate gyrus, right fusiform gyrus, occipital lobe and left cerebellum related.N1 latency are mainly related to the left cerebellum, which are negatively related to the left temporal gyrus, parahippocampal gyrus, right temporal gyrus and temporal gyrus, and the P2 latency is mainly related to the bilateral superior temporal gyrus, the left anterior lobe, the lingual gyrus, the posterior cingulate gyrus, the parapara lobule and the right temporal gyrus, and the left side. The anterior cingulate gyrus was negatively correlated.
4. the total score and factor score of 4. patients were negatively correlated with the right occipital gyrus on the right, and the scores of anxiety / somatization factor were negatively correlated with the left fusiform gyrus, right caudate nucleus, cerebellar vermis and bilateral cerebellum, and the lag factor was associated with the left frontal lobe, the anterior central gyrus, the anterior cingulate gyrus, and the upper temporal gyrus. The middle temporal gyrus and bilateral orbital frontal cortex, bilateral inferior frontal gyrus and bilateral occipital lobe are negatively correlated with bilateral occipital lobe; cognitive impairment factor is related to the left inferior frontal gyrus, the posterior central gyrus and the right occipital gyrus, and the sleep barrier factor is related to the left temporal superior temporal gyrus and right posterior central gyrus; and the body weight factor and bilateral side are both bilateral and bilateral. The parahippocampal gyrus was negatively correlated.
Conclusion:
1. compared with the health control, the volume of brain gray matter decreased in the first untreated women with depressive disorder, suggesting that the untreated women with depression have the characteristic gray matter volume abnormality.
2. The total score and factor score of depression scale were correlated with different brain area volume, suggesting that these different depressive symptoms may have different brain structure basis.
3. patients with cognitive event related potential P300 were abnormal, but had nothing to do with the severity of depression; the components of the cognitive event related potential P300 were related to the volume of multiple gray matter respectively, suggesting that the volume of gray matter in different brain regions had different effects on the different components of the cognitive event related potential P300, namely, the cognitive work of women with depression. The disturbance of energy is influenced by multiple brain regions or nerve loops, especially in the temporal lobe and the basal ganglia. The cognitive dysfunction of the patients with depressive disorder is relatively independent, and there are different brain structural bases from the depressive symptoms.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.4
【参考文献】
相关期刊论文 前1条
1 张璐璐;郑洪波;邓河晃;何柱国;;首发抑郁障碍认知功能与儿茶酚氧位甲基转移酶基因多态性的关联分析[J];实用医学杂志;2009年13期
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